| New isoprenylated flavonoids and adipogenesis-promoting constituents from Morus notabilis | |
Hu, Xiao1; Ji, Jun1; Wang, Meng1; Wu, Jin-Wei2; Zhao, Qin-Shi3 ; Wang, He-Yao2; Hou, Ai-Jun1
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| 通讯作者 | Hou, AJ (reprint author), Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China |
| 2011-08-01 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| ISSN | 0960-894X |
| 卷号 | 21期号:15页码:4441-4446 |
| 摘要 | Five new isoprenylated flavonoids, notabilisins A-E (1-5), and two known Diels-Alder adducts (6 and 7), were isolated from the twigs of Morus notabilis. Compounds 4 and 5 possess two novel pyran rings, which may be biogenetically derived from 3. Compounds 1 and 3 significantly promoted adipogenesis, characterized by increased lipid droplet and triglyceride content in 3T3L1 cells, and induced up-regulation of the expression of adipocyte-specific genes, aP2 and GLUT4. (C) 2011 Elsevier Ltd. All rights reserved. |
| 关键词 | Morus Notabilis Isoprenylated Flavonoids Adipogenesis |
| 学科领域 | Pharmacology & Pharmacy ; Chemistry |
| DOI | 10.1016/j.bmcl.2011.06.020 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000292729900012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/5527 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xiao,Ji, Jun,Wang, Meng,et al. New isoprenylated flavonoids and adipogenesis-promoting constituents from Morus notabilis[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(15):4441-4446. |
| APA | Hu, Xiao.,Ji, Jun.,Wang, Meng.,Wu, Jin-Wei.,Zhao, Qin-Shi.,...&Hou, Ai-Jun.(2011).New isoprenylated flavonoids and adipogenesis-promoting constituents from Morus notabilis.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(15),4441-4446. |
| MLA | Hu, Xiao,et al."New isoprenylated flavonoids and adipogenesis-promoting constituents from Morus notabilis".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.15(2011):4441-4446. |
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