| Notoginsenoside ST-4 inhibits virus penetration of herpes simplex virus in vitro | |
Pei, Ying1,2; Du, Qian1,2; Liao, Peng-Ying3,4; Chen, Zhen-Ping1,2; Wang, Dong3 ; Yang, Chong-Ren3,5; Kitazato, Kaio6; Wang, Yi-Fei1,2; Zhang, Ying-Jun3
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| Corresponding Author | Wang, YF (reprint author), Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China |
| 2011 | |
| Source Publication | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| ISSN | 1028-6020 |
| Volume | 13Issue:6Pages:498-504 |
| Abstract | Further study on steam-treated notoginseng, the roots of Panax notoginseng (Burk.) F.H. Chen (Araliaceae), which is a famous traditional Chinese medicine that is used both in raw and treated forms for a long time, led to the isolation of a new dammarane-type saponin, namely notoginsenoside ST-4. Its structure was elucidated to be 3,12,20(S)-tri-hydroxydammar-24-ene-3-O--d-xylopyranosyl-(12)--d-glucopyranosyl-(12)--d-glu-copyranoside, based on the detailed analyses of the 1D and 2D NMR spectral data and acidic hydrolysis. Notoginsenoside ST-4 was investigated for its antiviral activity on herpes simplex type 1 (HSV-1) and type 2 (HSV-2) in vitro. The 50% effective concentration (EC50) values, determined by plaque reduction assay, were 16.47 +/- 0.67 and 19.44 +/- 1.16M for HSV-1 and HSV-2, respectively, whereas the 50% cytotoxic concentration (CC50) determined by the XTT test on Vero cells was 510.64 +/- 4.56M. As analyzed by attachment assay and penetration assay based on plaque reduction assay, the antiviral activity of notoginsenoside ST-4 was principally due to the penetration inhibition effects, which was confirmed by fluorescence microscopy observation that notoginsenoside ST-4 blocked the penetration of virus. Therefore, notoginsenoside ST-4 might be a promising agent for herpes simplex virus infection. |
| Keyword | Notoginsenoside St-4 Herpes Simplex Virus Penetration Antiviral Activity |
| Subject Area | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| DOI | 10.1080/10286020.2011.571645 |
| Indexed By | SCI ; IC |
| Language | 英语 |
| WOS ID | WOS:000290986300004 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/5509 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China 2.Natl Engn Res Ctr Genet Med, Guangzhou 510630, Guangdong, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 4.Guangxi Tradit Chinese Med Univ, Nanning 530001, Peoples R China 5.Weihe Biotech Res & Dev Ctr, Yuxi 653101, Peoples R China 6.Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Nagasaki 8528521, Japan |
| Recommended Citation GB/T 7714 | Pei, Ying,Du, Qian,Liao, Peng-Ying,et al. Notoginsenoside ST-4 inhibits virus penetration of herpes simplex virus in vitro[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2011,13(6):498-504. |
| APA | Pei, Ying.,Du, Qian.,Liao, Peng-Ying.,Chen, Zhen-Ping.,Wang, Dong.,...&Zhang, Ying-Jun.(2011).Notoginsenoside ST-4 inhibits virus penetration of herpes simplex virus in vitro.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,13(6),498-504. |
| MLA | Pei, Ying,et al."Notoginsenoside ST-4 inhibits virus penetration of herpes simplex virus in vitro".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 13.6(2011):498-504. |
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