Notoginsenoside ST-4 inhibits virus penetration of herpes simplex virus in vitro
Pei, Ying1,2; Du, Qian1,2; Liao, Peng-Ying3,4; Chen, Zhen-Ping1,2; Wang, Dong3; Yang, Chong-Ren3,5; Kitazato, Kaio6; Wang, Yi-Fei1,2; Zhang, Ying-Jun3
2011
发表期刊JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN1028-6020
卷号13期号:6页码:498-504
摘要Further study on steam-treated notoginseng, the roots of Panax notoginseng (Burk.) F.H. Chen (Araliaceae), which is a famous traditional Chinese medicine that is used both in raw and treated forms for a long time, led to the isolation of a new dammarane-type saponin, namely notoginsenoside ST-4. Its structure was elucidated to be 3,12,20(S)-tri-hydroxydammar-24-ene-3-O--d-xylopyranosyl-(12)--d-glucopyranosyl-(12)--d-glu-copyranoside, based on the detailed analyses of the 1D and 2D NMR spectral data and acidic hydrolysis. Notoginsenoside ST-4 was investigated for its antiviral activity on herpes simplex type 1 (HSV-1) and type 2 (HSV-2) in vitro. The 50% effective concentration (EC50) values, determined by plaque reduction assay, were 16.47 +/- 0.67 and 19.44 +/- 1.16M for HSV-1 and HSV-2, respectively, whereas the 50% cytotoxic concentration (CC50) determined by the XTT test on Vero cells was 510.64 +/- 4.56M. As analyzed by attachment assay and penetration assay based on plaque reduction assay, the antiviral activity of notoginsenoside ST-4 was principally due to the penetration inhibition effects, which was confirmed by fluorescence microscopy observation that notoginsenoside ST-4 blocked the penetration of virus. Therefore, notoginsenoside ST-4 might be a promising agent for herpes simplex virus infection.
关键词Notoginsenoside St-4 Herpes Simplex Virus Penetration Antiviral Activity
资助信息National Nature Science Foundation of China (NSFC)[U0632010, 2008ZX09401-004, 2011CB915 503]; State Key Laboratory of Phytochemistry and Plant Resources in West China; Kunming Institute of Botany; Chinese Academy of Sciences[P2008-ZZ08]; Ministry of Education (MOE)[211]
学科领域Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
DOI10.1080/10286020.2011.571645
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000290986300004
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5509
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
2.Natl Engn Res Ctr Genet Med, Guangzhou 510630, Guangdong, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
4.Guangxi Tradit Chinese Med Univ, Nanning 530001, Peoples R China
5.Weihe Biotech Res & Dev Ctr, Yuxi 653101, Peoples R China
6.Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Nagasaki 8528521, Japan
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Pei, Ying,Du, Qian,Liao, Peng-Ying,et al. Notoginsenoside ST-4 inhibits virus penetration of herpes simplex virus in vitro[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2011,13(6):498-504.
APA Pei, Ying.,Du, Qian.,Liao, Peng-Ying.,Chen, Zhen-Ping.,Wang, Dong.,...&Zhang, Ying-Jun.(2011).Notoginsenoside ST-4 inhibits virus penetration of herpes simplex virus in vitro.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,13(6),498-504.
MLA Pei, Ying,et al."Notoginsenoside ST-4 inhibits virus penetration of herpes simplex virus in vitro".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 13.6(2011):498-504.
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