| Y Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin | |
| Zhu, Huan1,2; Zhou, Qin-Mei1,2; Peng, Cheng1,2; Chen, Ming-Hua3,4; Li, Xiao-Nian5; Lin, Da-Sheng6; Xiong, Liang1,2 | |
| 2017-07-01 | |
| Source Publication | FITOTERAPIA
 |
| ISSN | 0367-326X |
| Volume | 120Pages:67-71 |
| Abstract | Pocahemiketals A and B (1 and 2), two novel hemiketal sesquiterpenoids with unprecedented skeletons, were isolated from the essential oil of the aerial parts of Pogostemon cablin. In addition to a bicyclo[3.2.1]-carbon core, 1 and 2 possessed a hemiketal alpha,beta-unsaturated-gamma-lactone moiety. Their structures were determined by extensive spectroscopic analysis, electronic circular dichroism calculation, and single-crystal X-ray diffraction. Compound 2 exhibited significant vasorelaxant activity against phenylephrine-induced contraction of a rat aorta ring with the EC50 value of 16.32 mu M. |
| Keyword | Pogostemon Cablin Sesquiterpenoids Hemiketals Vasorelaxant Activity |
| Subject Area | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1016/j.fitote.2017.05.013 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000407404000009 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/54945 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Sichuan, Peoples R China 2.Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Sichuan, Peoples R China 3.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China 4.Peking Union Med Coll, Beijing 100050, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 6.Chengdu Huasun Grp Co Ltd, Chengdu 610075, Sichuan, Peoples R China |
| Recommended Citation GB/T 7714 | Zhu, Huan,Zhou, Qin-Mei,Peng, Cheng,et al. Y Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin[J]. FITOTERAPIA,2017,120:67-71. |
| APA | Zhu, Huan.,Zhou, Qin-Mei.,Peng, Cheng.,Chen, Ming-Hua.,Li, Xiao-Nian.,...&Xiong, Liang.(2017).Y Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin.FITOTERAPIA,120,67-71. |
| MLA | Zhu, Huan,et al."Y Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin".FITOTERAPIA 120(2017):67-71. |
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| 110.pdf（488KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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