Y Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin
Zhu, Huan1,2; Zhou, Qin-Mei1,2; Peng, Cheng1,2; Chen, Ming-Hua3,4; Li, Xiao-Nian5; Lin, Da-Sheng6; Xiong, Liang1,2
2017-07-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号120页码:67-71
摘要Pocahemiketals A and B (1 and 2), two novel hemiketal sesquiterpenoids with unprecedented skeletons, were isolated from the essential oil of the aerial parts of Pogostemon cablin. In addition to a bicyclo[3.2.1]-carbon core, 1 and 2 possessed a hemiketal alpha,beta-unsaturated-gamma-lactone moiety. Their structures were determined by extensive spectroscopic analysis, electronic circular dichroism calculation, and single-crystal X-ray diffraction. Compound 2 exhibited significant vasorelaxant activity against phenylephrine-induced contraction of a rat aorta ring with the EC50 value of 16.32 mu M.
关键词Pogostemon Cablin Sesquiterpenoids Hemiketals Vasorelaxant Activity
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/54945
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Sichuan, Peoples R China
2.Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Sichuan, Peoples R China
3.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
4.Peking Union Med Coll, Beijing 100050, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
6.Chengdu Huasun Grp Co Ltd, Chengdu 610075, Sichuan, Peoples R China
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Zhu, Huan,Zhou, Qin-Mei,Peng, Cheng,et al. Y Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin[J]. FITOTERAPIA,2017,120:67-71.
APA Zhu, Huan.,Zhou, Qin-Mei.,Peng, Cheng.,Chen, Ming-Hua.,Li, Xiao-Nian.,...&Xiong, Liang.(2017).Y Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin.FITOTERAPIA,120,67-71.
MLA Zhu, Huan,et al."Y Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin".FITOTERAPIA 120(2017):67-71.
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