Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)

doi:10.1021/jf202544w

	Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)
	Feng, Tao 1; Su, Jia 1; Ding, Zhi-Hui 1; Zheng, Yong-Tang 3,4; Li, Yan1 ; Leng, Ying 2; Liu, Ji-Kai 1
通讯作者	Liu, JK (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
	2011-11-09
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	0021-8561
卷号	59 期号:21 页码:11690-11695
摘要	Gingerols and their corresponding dehydration products shogaols were considered as the active principles of ginger, the rhizome of the plant Zingiber officinale, for its antioxidant, ant-inflammatory, and antitumor activities Ginger (Z. officinale) has been cultivated for thousands of years as a spice and for medicinal purposes in China. Tongling (Anhui province, China) has traditionally been regarded as an ideal cultivation place "Tongling White Ginger" enjoys a reputation for being one of the top gingers in China for its thin white peel, tender flesh, rich juice, and flavor In this study, we have isolated and identified two novel gingerdione dimers, bisgingerdiones A (1) and B (2), two new gingerol derivatives, (5R)-5-acetoxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one (3) and methyl (Z)-neral acetal-[6]-gingerdiol (4), and 38 known compounds (5-42) from rhizomes of Zingiber officinale collected from Tongling, China. Their structures were elucidated by means of spectroscopic methods Compounds 1-4 showed weak cytotoxic and anti-HIV-1 activities Compounds 6, 8, and 26 showed inhibitory activities against human and mouse 11 beta-HSD1 (11 beta-hydroxysteroid dehydrogenases) with IC50 values between 1 09 and 1 30 mu M.
关键词	Zingiber Officinale Tongling White Ginger Gingerdione Dimers Gingerol Derivatives 11 Beta-hsd
学科领域	Agriculture ; Chemistry ; Food Science & Technology
DOI	10.1021/jf202544w
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000296312000041
引用统计	被引频次：38[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/5493
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, Lab Mol Immunopharmacol, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Feng, Tao,Su, Jia,Ding, Zhi-Hui,et al. Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2011,59(21):11690-11695.
APA	Feng, Tao.,Su, Jia.,Ding, Zhi-Hui.,Zheng, Yong-Tang.,Li, Yan.,...&Liu, Ji-Kai.(2011).Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale).JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,59(21),11690-11695.
MLA	Feng, Tao,et al."Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 59.21(2011):11690-11695.

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