| Sesquiterpene and Norsesquiterpene Derivatives from Sanicula lamelligera and Their Biological Evaluation | |
Li, Xue-Song1,2; Zhou, Xiao-Jiang2; Zhang, Xing-Jie3; Su, Jia1; Li, Xue-Jing2; Yan, Yong-Ming1,4; Zheng, Yong-Tang3; Li, Yan1 ; Yang, Liu-Meng3; Cheng, Yong-Xian1
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| 通讯作者 | Cheng, YX (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China |
| 2011-06-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 74期号:6页码:1521-1525 |
| 摘要 | Fourteen sesquiterpene and norsesquiterpene derivatives, comprising six different carbon skeletons, were isolated from Sanicula lamelligera. Saniculamoid A1 (1a) is an oxidation product of saniculamoid A (1), created by the transition of a formyl group to a carboxylic acid group after a period of storage in air. The known compounds 5-14 were identified in Sanicula plants for the first time. The compounds were evaluated for their anti-HIV-1, cytostatic, and nitric-oxide-production-inhibiting activities using in vitro cellular assays. The results showed that 1,5-naphthalenediol inhibited nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC50 value of 28.1 mu M and was active toward five cancer cell lines with IC50 values in the 31.1-41.6 mu M range. |
| 关键词 | Europaea l Litsea-verticillata Planum l Constituents Saponins Terpenoids Leaves |
| 学科领域 | Plant Sciences ; Pharmacology & Pharmacy |
| DOI | 10.1021/np200146x |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000291920600025 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/5479 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China 4.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xue-Song,Zhou, Xiao-Jiang,Zhang, Xing-Jie,et al. Sesquiterpene and Norsesquiterpene Derivatives from Sanicula lamelligera and Their Biological Evaluation[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(6):1521-1525. |
| APA | Li, Xue-Song.,Zhou, Xiao-Jiang.,Zhang, Xing-Jie.,Su, Jia.,Li, Xue-Jing.,...&Cheng, Yong-Xian.(2011).Sesquiterpene and Norsesquiterpene Derivatives from Sanicula lamelligera and Their Biological Evaluation.JOURNAL OF NATURAL PRODUCTS,74(6),1521-1525. |
| MLA | Li, Xue-Song,et al."Sesquiterpene and Norsesquiterpene Derivatives from Sanicula lamelligera and Their Biological Evaluation".JOURNAL OF NATURAL PRODUCTS 74.6(2011):1521-1525. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 201203190053.pdf（932KB） | 开放获取 | -- | 浏览 请求全文 | |||
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