Sesquiterpene and Norsesquiterpene Derivatives from Sanicula lamelligera and Their Biological Evaluation
Li, Xue-Song1,2; Zhou, Xiao-Jiang2; Zhang, Xing-Jie3; Su, Jia1; Li, Xue-Jing2; Yan, Yong-Ming1,4; Zheng, Yong-Tang3; Li, Yan1; Yang, Liu-Meng3; Cheng, Yong-Xian1
2011-06-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号74期号:6页码:1521-1525
摘要Fourteen sesquiterpene and norsesquiterpene derivatives, comprising six different carbon skeletons, were isolated from Sanicula lamelligera. Saniculamoid A1 (1a) is an oxidation product of saniculamoid A (1), created by the transition of a formyl group to a carboxylic acid group after a period of storage in air. The known compounds 5-14 were identified in Sanicula plants for the first time. The compounds were evaluated for their anti-HIV-1, cytostatic, and nitric-oxide-production-inhibiting activities using in vitro cellular assays. The results showed that 1,5-naphthalenediol inhibited nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC50 value of 28.1 mu M and was active toward five cancer cell lines with IC50 values in the 31.1-41.6 mu M range.
关键词Europaea l Litsea-verticillata Planum l Constituents Saponins Terpenoids Leaves
资助信息Talent Scholarship of Yunnan Youth[2007PY01]; Traditional Chinese Medicine Scientific Research Fund of Hunan Province[2008023]; State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources; Ministry of Science and Technology of China[2008ZX09401-004]
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5479
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
4.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
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Li, Xue-Song,Zhou, Xiao-Jiang,Zhang, Xing-Jie,et al. Sesquiterpene and Norsesquiterpene Derivatives from Sanicula lamelligera and Their Biological Evaluation[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(6):1521-1525.
APA Li, Xue-Song.,Zhou, Xiao-Jiang.,Zhang, Xing-Jie.,Su, Jia.,Li, Xue-Jing.,...&Cheng, Yong-Xian.(2011).Sesquiterpene and Norsesquiterpene Derivatives from Sanicula lamelligera and Their Biological Evaluation.JOURNAL OF NATURAL PRODUCTS,74(6),1521-1525.
MLA Li, Xue-Song,et al."Sesquiterpene and Norsesquiterpene Derivatives from Sanicula lamelligera and Their Biological Evaluation".JOURNAL OF NATURAL PRODUCTS 74.6(2011):1521-1525.
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