| Macrophyllionium and Macrophyllines A and B, Oxindole Alkaloids from Uncaria macrophylla | |
Wang, Kou2,3; Zhou, Xiao-Yu1; Wang, Yuan-Yuan2; Li, Ming-Ming2,3; Li, Yin-Shan4; Peng, Li-Yan2; Cheng, Xiao2; Li, Yan2 ; Wang, Yi-Ping1; Zhao, Qin-Shi2
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| 通讯作者 | Wang, YP (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 2011 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 74期号:1页码:12-15 |
| 摘要 | An unusual oxindole alkaloid inner salt, macrophyllionium (1), and a pair of new tetracyclic oxindole alkaloids, macrophyllines A (2) and B (3), together with six known alkaloids, were isolated from the aerial parts of Uncaria macrophylla. Corynantheidine (8) exhibited moderate cytotoxicity against HL-60 and SW480 cells with IC(50) values of 13.96 and 23.28 mu M, respectively. Dihydrocorynantheine (9) exhibited significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 mu g/mL). In addition, compounds 2, 6, and 9 showed weak inhibitory action on KO-induced contraction. |
| 关键词 | Indole Alkaloids Isorhynchophylline Rhynchophylline Proliferation Hooks C-13 |
| 学科领域 | Plant Sciences ; Pharmacology & Pharmacy |
| DOI | 10.1021/np1004938 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000286577800003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/5473 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 4.Dali Univ, Coll Pharm, Dali 671002, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Kou,Zhou, Xiao-Yu,Wang, Yuan-Yuan,et al. Macrophyllionium and Macrophyllines A and B, Oxindole Alkaloids from Uncaria macrophylla[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(1):12-15. |
| APA | Wang, Kou.,Zhou, Xiao-Yu.,Wang, Yuan-Yuan.,Li, Ming-Ming.,Li, Yin-Shan.,...&Zhao, Qin-Shi.(2011).Macrophyllionium and Macrophyllines A and B, Oxindole Alkaloids from Uncaria macrophylla.JOURNAL OF NATURAL PRODUCTS,74(1),12-15. |
| MLA | Wang, Kou,et al."Macrophyllionium and Macrophyllines A and B, Oxindole Alkaloids from Uncaria macrophylla".JOURNAL OF NATURAL PRODUCTS 74.1(2011):12-15. |
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