Macrophyllionium and Macrophyllines A and B, Oxindole Alkaloids from Uncaria macrophylla
Wang, Kou2,3; Zhou, Xiao-Yu1; Wang, Yuan-Yuan2; Li, Ming-Ming2,3; Li, Yin-Shan4; Peng, Li-Yan2; Cheng, Xiao2; Li, Yan2; Wang, Yi-Ping1; Zhao, Qin-Shi2
Corresponding AuthorWang, YP (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2011
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume74Issue:1Pages:12-15
AbstractAn unusual oxindole alkaloid inner salt, macrophyllionium (1), and a pair of new tetracyclic oxindole alkaloids, macrophyllines A (2) and B (3), together with six known alkaloids, were isolated from the aerial parts of Uncaria macrophylla. Corynantheidine (8) exhibited moderate cytotoxicity against HL-60 and SW480 cells with IC(50) values of 13.96 and 23.28 mu M, respectively. Dihydrocorynantheine (9) exhibited significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 mu g/mL). In addition, compounds 2, 6, and 9 showed weak inhibitory action on KO-induced contraction.
KeywordIndole Alkaloids Isorhynchophylline Rhynchophylline Proliferation Hooks C-13
Subject AreaPlant Sciences ; Pharmacology & Pharmacy
DOI10.1021/np1004938
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000286577800003
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/5473
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
4.Dali Univ, Coll Pharm, Dali 671002, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Wang, Kou,Zhou, Xiao-Yu,Wang, Yuan-Yuan,et al. Macrophyllionium and Macrophyllines A and B, Oxindole Alkaloids from Uncaria macrophylla[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(1):12-15.
APA Wang, Kou.,Zhou, Xiao-Yu.,Wang, Yuan-Yuan.,Li, Ming-Ming.,Li, Yin-Shan.,...&Zhao, Qin-Shi.(2011).Macrophyllionium and Macrophyllines A and B, Oxindole Alkaloids from Uncaria macrophylla.JOURNAL OF NATURAL PRODUCTS,74(1),12-15.
MLA Wang, Kou,et al."Macrophyllionium and Macrophyllines A and B, Oxindole Alkaloids from Uncaria macrophylla".JOURNAL OF NATURAL PRODUCTS 74.1(2011):12-15.
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