| Lindenane Disesquiterpenoids with Anti-HIV-1 Activity from Chloranthus japonicus | |
Fang, Ping-Lei3,4; Cao, Ying-Li1,2; Yan, Huan3; Pan, Li-Li3,4; Liu, Shu-Cong1,2; Gong, Ning-Bo1,2; Lue, Yang1,2; Chen, Chang-Xiang3 ; Zhong, Hui-Min4; Guo, Ying1,2; Liu, Hai-Yang3
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| 通讯作者 | Guo, Y (reprint author), Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, Beijing 100050, Peoples R China |
| 2011-06-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 74期号:6页码:1408-1413 |
| 摘要 | Five new lindenane disesquiterpenoids, chlorajaponilides A-E (1-5), together with 11 known analogues were isolated from whole plants of Chloranthus japonicus. The structure and absolute configuration of 1 was confirmed by X-ray crystallography. Compounds 1 and 2 represent the first examples of lindenane disesquiterpenoids with a C-5 hydroxy group and a C-4- C-15 double bond. Compounds 8, 9, 11, and 12 showed anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. Shizukaol B (8) exhibited the best activity against HWwt, HIVRT-K103N, and HIVRT-K103N with EC50 values of 0.22, 0.47, and 0.50, mu M, respectively. Compounds 8, 9, 11, and 12 had significant cytotoxicities against C8166 cells with CC50 values of 0.020, 0.089, 0.047, and 0.022, respectively, and exhibited inhibitory activities against HIV-I with EC50 values of 0.0014, 0.016, 0.0043, and 0.0033,mu M, respectively. |
| 关键词 | Chemical-constituents Sesquiterpene Dimer Plants Spicatus Serratus Sieb |
| 学科领域 | Plant Sciences ; Pharmacology & Pharmacy |
| DOI | 10.1021/np200087d |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000291920600009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/5471 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, Beijing 100050, Peoples R China 2.Peking Union Med Coll, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 4.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Ping-Lei,Cao, Ying-Li,Yan, Huan,et al. Lindenane Disesquiterpenoids with Anti-HIV-1 Activity from Chloranthus japonicus[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(6):1408-1413. |
| APA | Fang, Ping-Lei.,Cao, Ying-Li.,Yan, Huan.,Pan, Li-Li.,Liu, Shu-Cong.,...&Liu, Hai-Yang.(2011).Lindenane Disesquiterpenoids with Anti-HIV-1 Activity from Chloranthus japonicus.JOURNAL OF NATURAL PRODUCTS,74(6),1408-1413. |
| MLA | Fang, Ping-Lei,et al."Lindenane Disesquiterpenoids with Anti-HIV-1 Activity from Chloranthus japonicus".JOURNAL OF NATURAL PRODUCTS 74.6(2011):1408-1413. |
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