Lindenane Disesquiterpenoids with Anti-HIV-1 Activity from Chloranthus japonicus
Fang, Ping-Lei3,4; Cao, Ying-Li1,2; Yan, Huan3; Pan, Li-Li3,4; Liu, Shu-Cong1,2; Gong, Ning-Bo1,2; Lue, Yang1,2; Chen, Chang-Xiang3; Zhong, Hui-Min4; Guo, Ying1,2; Liu, Hai-Yang3
2011-06-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号74期号:6页码:1408-1413
摘要Five new lindenane disesquiterpenoids, chlorajaponilides A-E (1-5), together with 11 known analogues were isolated from whole plants of Chloranthus japonicus. The structure and absolute configuration of 1 was confirmed by X-ray crystallography. Compounds 1 and 2 represent the first examples of lindenane disesquiterpenoids with a C-5 hydroxy group and a C-4- C-15 double bond. Compounds 8, 9, 11, and 12 showed anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. Shizukaol B (8) exhibited the best activity against HWwt, HIVRT-K103N, and HIVRT-K103N with EC50 values of 0.22, 0.47, and 0.50, mu M, respectively. Compounds 8, 9, 11, and 12 had significant cytotoxicities against C8166 cells with CC50 values of 0.020, 0.089, 0.047, and 0.022, respectively, and exhibited inhibitory activities against HIV-I with EC50 values of 0.0014, 0.016, 0.0043, and 0.0033,mu M, respectively.
关键词Chemical-constituents Sesquiterpene Dimer Plants Spicatus Serratus Sieb
资助信息National Natural Science Funding of China[81072543]; CAS[KSCX2-EW-Q-10]; State Key Laboratory of Phytochemistry and Plant Resources in West China[P2009-KF04]
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1021/np200087d
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000291920600009
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5471
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, Beijing 100050, Peoples R China
2.Peking Union Med Coll, Beijing 100050, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
4.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China
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Fang, Ping-Lei,Cao, Ying-Li,Yan, Huan,et al. Lindenane Disesquiterpenoids with Anti-HIV-1 Activity from Chloranthus japonicus[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(6):1408-1413.
APA Fang, Ping-Lei.,Cao, Ying-Li.,Yan, Huan.,Pan, Li-Li.,Liu, Shu-Cong.,...&Liu, Hai-Yang.(2011).Lindenane Disesquiterpenoids with Anti-HIV-1 Activity from Chloranthus japonicus.JOURNAL OF NATURAL PRODUCTS,74(6),1408-1413.
MLA Fang, Ping-Lei,et al."Lindenane Disesquiterpenoids with Anti-HIV-1 Activity from Chloranthus japonicus".JOURNAL OF NATURAL PRODUCTS 74.6(2011):1408-1413.
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