Cyclopeptide Alkaloids from Ziziphus apetala
Han, Jing1,4; Ji, Chang-Jiu1,4; He, Wen-Jun1; Shen, Yu2,4; Leng, Ying2; Xu, Wen-Yan1; Fan, Jun-Ting1; Zeng, Guang-Zhi1; Kong, Ling-Dong3; Tan, Ning-Hua1
2011-12-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号74期号:12页码:2571-2575
摘要Six novel Ia(3)-type cyclopeptide alkaloids (1-6) were isolated from stems of Ziziphus apetala. Compound 5 and the known compounds mauritine A (7) and mauritine F (8) were isolated from the roots. Their structures were determined by spectroscopic analyses and chemical methods. The total alkaloids from the roots and the isolated cyclopeptide alkaloids were tested for antidepressant behavior on mice, cytotoxicity, and 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) inhibition in vitro. Only mauritine A (7) showed inhibitory activity on 11 beta-HSD1, with IC50 values of 52.0 (human) and 31.2 mu g/mL (mouse).
资助信息National Natural Science Foundation of China[30725048, 91013002, U1032602]; National New Drug Innovation Major Project of China[2011ZX09307-002-02]; National Basic Research Program of China[2009CB522300]; Chinese Academy of Sciences[KSCX2-YW-R-177]
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1021/np200755t
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000298315800011
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5465
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Nanjing Univ, Nanjing 210093, Jiangsu, Peoples R China
4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Han, Jing,Ji, Chang-Jiu,He, Wen-Jun,et al. Cyclopeptide Alkaloids from Ziziphus apetala[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(12):2571-2575.
APA Han, Jing.,Ji, Chang-Jiu.,He, Wen-Jun.,Shen, Yu.,Leng, Ying.,...&Tan, Ning-Hua.(2011).Cyclopeptide Alkaloids from Ziziphus apetala.JOURNAL OF NATURAL PRODUCTS,74(12),2571-2575.
MLA Han, Jing,et al."Cyclopeptide Alkaloids from Ziziphus apetala".JOURNAL OF NATURAL PRODUCTS 74.12(2011):2571-2575.
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