Cyclopeptide Alkaloids from Ziziphus apetala

doi:10.1021/np200755t

	Cyclopeptide Alkaloids from Ziziphus apetala
	Han, Jing 1,4; Ji, Chang-Jiu 1,4; He, Wen-Jun 1; Shen, Yu 2,4; Leng, Ying 2; Xu, Wen-Yan 1; Fan, Jun-Ting 1; Zeng, Guang-Zhi 1; Kong, Ling-Dong 3; Tan, Ning-Hua 1
通讯作者	Tan, NH (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
	2011-12-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	74 期号:12 页码:2571-2575
摘要	Six novel Ia(3)-type cyclopeptide alkaloids (1-6) were isolated from stems of Ziziphus apetala. Compound 5 and the known compounds mauritine A (7) and mauritine F (8) were isolated from the roots. Their structures were determined by spectroscopic analyses and chemical methods. The total alkaloids from the roots and the isolated cyclopeptide alkaloids were tested for antidepressant behavior on mice, cytotoxicity, and 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) inhibition in vitro. Only mauritine A (7) showed inhibitory activity on 11 beta-HSD1, with IC50 values of 52.0 (human) and 31.2 mu g/mL (mouse).
学科领域	Plant Sciences ; Pharmacology & Pharmacy
DOI	10.1021/np200755t
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000298315800011
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/5465
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Nanjing Univ, Nanjing 210093, Jiangsu, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Han, Jing,Ji, Chang-Jiu,He, Wen-Jun,et al. Cyclopeptide Alkaloids from Ziziphus apetala[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(12):2571-2575.
APA	Han, Jing.,Ji, Chang-Jiu.,He, Wen-Jun.,Shen, Yu.,Leng, Ying.,...&Tan, Ning-Hua.(2011).Cyclopeptide Alkaloids from Ziziphus apetala.JOURNAL OF NATURAL PRODUCTS,74(12),2571-2575.
MLA	Han, Jing,et al."Cyclopeptide Alkaloids from Ziziphus apetala".JOURNAL OF NATURAL PRODUCTS 74.12(2011):2571-2575.

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