| Bioactive Compounds from the Aerial Parts of Brachystemma calycinum and Structural Revision of an Octacyclopeptide | |
| Zhao, Jun2; Zhou, Li-Li1; Li, Xi3; Xiao, Hong-Bin4; Hou, Fan-Fan1; Cheng, Yong-Xian2 | |
| 通讯作者 | Hou, FF (reprint author), So Med Univ, Nanfang Hosp, Div Nephrol, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Peoples R China |
| 2011-06-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
 |
| ISSN | 0163-3864 |
| 卷号 | 74期号:6页码:1392-1400 |
| 摘要 | Four new cyclic peptides, brachystemins F-I (1-4), and 11 known compounds were isolated from the aerial parts of Brachystemma calycinim. The absolute configurations of compounds 1-4 were assigned using Marfey's method. The structure of compound 5 was revised from cyclo-(Pro(1)-Phe(2)-Leu(3)-Ala(4)-Thr(5)-Pro(6)-Ala(7)-Gly(8)) to cyclo-(Pro(1)-Pro(2)-Ala(3)-Gly(4)-Leu(5)-Ala(6)-Thr(7)-Phe(8)) with QTOF/MS and X-ray diffraction analysis. The N-containing compounds were assessed for their inhibitory effects on the secretion of monocyte chemokine ligand 2 (CCL-2), interleukin 6 (IL-6), and collagen IV against high-glucose-stimulated mesangial cells. Compound 5 was evaluated for its effects on collagen I, reactive oxygen species (ROS), superoxide anion (O(2)(center dot-)) production, and cell viability in mesangial cells, and on nitric oxide (NO) production in macrophage cells. |
| 关键词 | Diabetic-nephropathy Inflammation Expression Alkaloids Collagen Glucose Alpha Beta |
| 学科领域 | Plant Sciences ; Pharmacology & Pharmacy |
| DOI | 10.1021/np200048u |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000291920600007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/5461 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.So Med Univ, Nanfang Hosp, Div Nephrol, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Jun,Zhou, Li-Li,Li, Xi,et al. Bioactive Compounds from the Aerial Parts of Brachystemma calycinum and Structural Revision of an Octacyclopeptide[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(6):1392-1400. |
| APA | Zhao, Jun,Zhou, Li-Li,Li, Xi,Xiao, Hong-Bin,Hou, Fan-Fan,&Cheng, Yong-Xian.(2011).Bioactive Compounds from the Aerial Parts of Brachystemma calycinum and Structural Revision of an Octacyclopeptide.JOURNAL OF NATURAL PRODUCTS,74(6),1392-1400. |
| MLA | Zhao, Jun,et al."Bioactive Compounds from the Aerial Parts of Brachystemma calycinum and Structural Revision of an Octacyclopeptide".JOURNAL OF NATURAL PRODUCTS 74.6(2011):1392-1400. |
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