Bioactive Compounds from the Aerial Parts of Brachystemma calycinum and Structural Revision of an Octacyclopeptide
Zhao, Jun2; Zhou, Li-Li1; Li, Xi3; Xiao, Hong-Bin4; Hou, Fan-Fan1; Cheng, Yong-Xian2
2011-06-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号74期号:6页码:1392-1400
摘要Four new cyclic peptides, brachystemins F-I (1-4), and 11 known compounds were isolated from the aerial parts of Brachystemma calycinim. The absolute configurations of compounds 1-4 were assigned using Marfey's method. The structure of compound 5 was revised from cyclo-(Pro(1)-Phe(2)-Leu(3)-Ala(4)-Thr(5)-Pro(6)-Ala(7)-Gly(8)) to cyclo-(Pro(1)-Pro(2)-Ala(3)-Gly(4)-Leu(5)-Ala(6)-Thr(7)-Phe(8)) with QTOF/MS and X-ray diffraction analysis. The N-containing compounds were assessed for their inhibitory effects on the secretion of monocyte chemokine ligand 2 (CCL-2), interleukin 6 (IL-6), and collagen IV against high-glucose-stimulated mesangial cells. Compound 5 was evaluated for its effects on collagen I, reactive oxygen species (ROS), superoxide anion (O(2)(center dot-)) production, and cell viability in mesangial cells, and on nitric oxide (NO) production in macrophage cells.
关键词Diabetic-nephropathy Inflammation Expression Alkaloids Collagen Glucose Alpha Beta
资助信息National Natural Science Foundation of China[30700059]; Talent Scholarship of Yunnan Youth[2007PY01-48]; State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources; Ministry of Science and Technology of China[2008ZX09401-004]; Chinese Academy of Sciences[KSCX2-EW-R-15]
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1021/np200048u
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000291920600007
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5461
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.So Med Univ, Nanfang Hosp, Div Nephrol, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
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Zhao, Jun,Zhou, Li-Li,Li, Xi,et al. Bioactive Compounds from the Aerial Parts of Brachystemma calycinum and Structural Revision of an Octacyclopeptide[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(6):1392-1400.
APA Zhao, Jun,Zhou, Li-Li,Li, Xi,Xiao, Hong-Bin,Hou, Fan-Fan,&Cheng, Yong-Xian.(2011).Bioactive Compounds from the Aerial Parts of Brachystemma calycinum and Structural Revision of an Octacyclopeptide.JOURNAL OF NATURAL PRODUCTS,74(6),1392-1400.
MLA Zhao, Jun,et al."Bioactive Compounds from the Aerial Parts of Brachystemma calycinum and Structural Revision of an Octacyclopeptide".JOURNAL OF NATURAL PRODUCTS 74.6(2011):1392-1400.
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