| Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway | |
Fang, Zhong-Ze1,2; Nian, Yin2,3 ; Li, Wei1,2; Wu, Jing-Jing1; Ge, Guang-Bo1,2; Dong, Pei-Pei1,2; Zhang, Yan-Yan1,2; Qiu, Ming-Hua3; Liu, Lei4; Yang, Ling1
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| 通讯作者 | Yang, L (reprint author), Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China |
| 2011 | |
| 发表期刊 | PHYTOTHERAPY RESEARCH
 |
| ISSN | 0951-418X |
| 卷号 | 25期号:1页码:17-24 |
| 摘要 | The present study was carried out to investigate the antitumor activity of five cycloartane triterpenoids isolated from Cimicifuga yunnanensis on the breast cancer cell line MCF7 and its corresponding drug resistant subline R-MCF7, including cimigenol-3-O-beta-D-xylopyranoside (compound 1), 25-O-acetylcimigenol-3-O-beta-D-xylopyranoside (compound 2), 25-chlorodeoxycimigenol-3-O-beta-D-xylopyranoside (compound 3), 25-O-acetylcimigenol-3-O-alpha-L-arabinopyranoside (compound 4) and 23-O-acetylcimigenol-3-O-beta-D-xylopyranoside (compound 5). The results showed that compounds 2-5 have relatively high antitumor activity on both MCF7 and R-MCF7 cells. The involvement of apoptosis as a major cause of cycloartane triterpenoids-induced cell death was further confirmed. The results of RT-PCR showed that compounds 2-5 increased the expression of p53 and bax, which led to the loss of mitochondrial potential and then resulted in the activation of caspase-7. These findings collectively demonstrated that compounds 2-5 induced apoptosis of MCF7 via p53-dependent mitochondrial pathway. Copyright (C) 2010 John Wiley & Sons, Ltd. |
| 关键词 | Cycloartane Triterpenoids Mcf7 P53 Apoptosis Mitochondrial Membrane Potential Caspase-7 |
| 学科领域 | Pharmacology & Pharmacy |
| DOI | 10.1002/ptr.3222 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000285848700003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/5447 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 4.Shenzhen Childrens Hosp, Shenzhen 518100, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Zhong-Ze,Nian, Yin,Li, Wei,et al. Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway[J]. PHYTOTHERAPY RESEARCH,2011,25(1):17-24. |
| APA | Fang, Zhong-Ze.,Nian, Yin.,Li, Wei.,Wu, Jing-Jing.,Ge, Guang-Bo.,...&Yang, Ling.(2011).Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway.PHYTOTHERAPY RESEARCH,25(1),17-24. |
| MLA | Fang, Zhong-Ze,et al."Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway".PHYTOTHERAPY RESEARCH 25.1(2011):17-24. |
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