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题名: Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway
作者: Fang, Zhong-Ze1, 2; Nian, Yin2, 3; Li, Wei1, 2; Wu, Jing-Jing1; Ge, Guang-Bo1, 2; Dong, Pei-Pei1, 2; Zhang, Yan-Yan1, 2; null(邱明华)3; Liu, Lei4; Yang, Ling1
刊名: PHYTOTHERAPY RESEARCH
关键词: cycloartane triterpenoids ; MCF7 ; p53 ; apoptosis ; mitochondrial membrane potential ; caspase-7
英文摘要: The present study was carried out to investigate the antitumor activity of five cycloartane triterpenoids isolated from Cimicifuga yunnanensis on the breast cancer cell line MCF7 and its corresponding drug resistant subline R-MCF7, including cimigenol-3-O-beta-D-xylopyranoside (compound 1), 25-O-acetylcimigenol-3-O-beta-D-xylopyranoside (compound 2), 25-chlorodeoxycimigenol-3-O-beta-D-xylopyranoside (compound 3), 25-O-acetylcimigenol-3-O-alpha-L-arabinopyranoside (compound 4) and 23-O-acetylcimigenol-3-O-beta-D-xylopyranoside (compound 5). The results showed that compounds 2-5 have relatively high antitumor activity on both MCF7 and R-MCF7 cells. The involvement of apoptosis as a major cause of cycloartane triterpenoids-induced cell death was further confirmed. The results of RT-PCR showed that compounds 2-5 increased the expression of p53 and bax, which led to the loss of mitochondrial potential and then resulted in the activation of caspase-7. These findings collectively demonstrated that compounds 2-5 induced apoptosis of MCF7 via p53-dependent mitochondrial pathway. Copyright (C) 2010 John Wiley & Sons, Ltd.
出版日期: 2011
卷号: 25, 期号:1, 页码:17-24
语种: 英语
收录类别: SCI
学科分类: Pharmacology & Pharmacy
ISSN号: 0951-418X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5447
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
4.Shenzhen Childrens Hosp, Shenzhen 518100, Peoples R China

Recommended Citation:
Fang, ZZ; Nian, Y; Li, W; Wu, JJ; Ge, GB; Dong, PP; Zhang, YY; Qiu, MH; Liu, L; Yang, L.Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway,PHYTOTHERAPY RESEARCH,2011,25(1):17-24
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