Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway
Fang, Zhong-Ze1,2; Nian, Yin2,3; Li, Wei1,2; Wu, Jing-Jing1; Ge, Guang-Bo1,2; Dong, Pei-Pei1,2; Zhang, Yan-Yan1,2; Qiu, Ming-Hua3; Liu, Lei4; Yang, Ling1
2011
发表期刊PHYTOTHERAPY RESEARCH
ISSN0951-418X
卷号25期号:1页码:17-24
摘要The present study was carried out to investigate the antitumor activity of five cycloartane triterpenoids isolated from Cimicifuga yunnanensis on the breast cancer cell line MCF7 and its corresponding drug resistant subline R-MCF7, including cimigenol-3-O-beta-D-xylopyranoside (compound 1), 25-O-acetylcimigenol-3-O-beta-D-xylopyranoside (compound 2), 25-chlorodeoxycimigenol-3-O-beta-D-xylopyranoside (compound 3), 25-O-acetylcimigenol-3-O-alpha-L-arabinopyranoside (compound 4) and 23-O-acetylcimigenol-3-O-beta-D-xylopyranoside (compound 5). The results showed that compounds 2-5 have relatively high antitumor activity on both MCF7 and R-MCF7 cells. The involvement of apoptosis as a major cause of cycloartane triterpenoids-induced cell death was further confirmed. The results of RT-PCR showed that compounds 2-5 increased the expression of p53 and bax, which led to the loss of mitochondrial potential and then resulted in the activation of caspase-7. These findings collectively demonstrated that compounds 2-5 induced apoptosis of MCF7 via p53-dependent mitochondrial pathway. Copyright (C) 2010 John Wiley & Sons, Ltd.
关键词Cycloartane Triterpenoids Mcf7 P53 Apoptosis Mitochondrial Membrane Potential Caspase-7
资助信息Ministry of Science and Technology of China[2009CB522808, 2008IM020900]; National Natural Science Foundation of China[30772636]
学科领域Pharmacology & Pharmacy
DOI10.1002/ptr.3222
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000285848700003
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5447
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
4.Shenzhen Childrens Hosp, Shenzhen 518100, Peoples R China
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Fang, Zhong-Ze,Nian, Yin,Li, Wei,et al. Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway[J]. PHYTOTHERAPY RESEARCH,2011,25(1):17-24.
APA Fang, Zhong-Ze.,Nian, Yin.,Li, Wei.,Wu, Jing-Jing.,Ge, Guang-Bo.,...&Yang, Ling.(2011).Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway.PHYTOTHERAPY RESEARCH,25(1),17-24.
MLA Fang, Zhong-Ze,et al."Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway".PHYTOTHERAPY RESEARCH 25.1(2011):17-24.
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