| Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L. | |
| Zhao, You-Xing1; Liang, Wen-Juan3; Fan, Hui-Jin2; Ma, Qing-Yun1; Tian, Wei-Xi2; Dai, Hao-Fu1; Jiang, He-Zhong3; Li, Ning4; Ma, Xiao-Feng2 | |
| 通讯作者 | Zhao, YX (reprint author), Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China |
| 2011-08-16 | |
| 发表期刊 | CARBOHYDRATE RESEARCH
 |
| ISSN | 0008-6215 |
| 卷号 | 346期号:11页码:1302-1306 |
| 摘要 | Natural products inhibiting fatty acid synthase (FAS) are appearing as potential therapeutic agents to treat cancer and obesity. The bioassay-guided chemical investigation of the hulls of Nephelium lappaceurn L. resulted in the isolation of ten compounds (1-10) mainly including flavonoids and oleane-type triterpene oligoglycosides, in which all of the compounds were isolated from this plant for the first time. Additionally, compounds 8 and 9 were new hederagenin derivatives and were elucidated as hederagenin 3-O-(2,3-di-O-acetyl-alpha-L-arabinofuranosyl)-(1 -> 3)-[alpha-L-rhamnopyranosyl(1 -> 2)]-beta-L-arabinopyranoside and hederagenin 3-O-(3-O-acetyl-alpha-L-arabinofuranosyl)-(1 -> 3)-[alpha-L-rhamnopyranosyl-(1 -> 2)]-beta-L-arabinopyranoside, respectively. All these isolates were evaluated for inhibitory activities of FAS, which showed these isolates had inhibitory activity against FAS with IC50 values ranging from 6.69 to 204.40 mu M, comparable to the known FAS inhibitor EGCG (IC50 = 51.97 mu M). The study indicates that the hulls of Nephelium lappaceum L could be considered as potential sources of promising FAS inhibitors and the oleane-type triterpene oligoglycosides could be considered as another type of natural FAS inhibitors. (C) 2011 Elsevier Ltd. All rights reserved. |
| 关键词 | Tea Epigallocatechin Gallate Antitumor-activity Food-intake Cancer Orlistat Apoptosis Rambutan Obesity Enzyme Fruit |
| 学科领域 | Biochemistry & Molecular Biology ; Chemistry |
| DOI | 10.1016/j.carres.2011.04.028 |
| 收录类别 | sci |
| 语种 | 英语 |
| WOS记录号 | WOS:000292858600005 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/5381 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China 2.Chinese Acad Sci, Coll Life Sci, Grad Univ, Beijing 100049, Peoples R China 3.Chinese Acad Sci Kunming, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 4.Anhui Univ, Sch Life Sci, Hefei 230039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, You-Xing,Liang, Wen-Juan,Fan, Hui-Jin,et al. Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L.[J]. CARBOHYDRATE RESEARCH,2011,346(11):1302-1306. |
| APA | Zhao, You-Xing.,Liang, Wen-Juan.,Fan, Hui-Jin.,Ma, Qing-Yun.,Tian, Wei-Xi.,...&Ma, Xiao-Feng.(2011).Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L..CARBOHYDRATE RESEARCH,346(11),1302-1306. |
| MLA | Zhao, You-Xing,et al."Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L.".CARBOHYDRATE RESEARCH 346.11(2011):1302-1306. |
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