Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L.
Zhao, You-Xing1; Liang, Wen-Juan3; Fan, Hui-Jin2; Ma, Qing-Yun1; Tian, Wei-Xi2; Dai, Hao-Fu1; Jiang, He-Zhong3; Li, Ning4; Ma, Xiao-Feng2
2011-08-16
发表期刊CARBOHYDRATE RESEARCH
ISSN0008-6215
卷号346期号:11页码:1302-1306
摘要Natural products inhibiting fatty acid synthase (FAS) are appearing as potential therapeutic agents to treat cancer and obesity. The bioassay-guided chemical investigation of the hulls of Nephelium lappaceurn L. resulted in the isolation of ten compounds (1-10) mainly including flavonoids and oleane-type triterpene oligoglycosides, in which all of the compounds were isolated from this plant for the first time. Additionally, compounds 8 and 9 were new hederagenin derivatives and were elucidated as hederagenin 3-O-(2,3-di-O-acetyl-alpha-L-arabinofuranosyl)-(1 -> 3)-[alpha-L-rhamnopyranosyl(1 -> 2)]-beta-L-arabinopyranoside and hederagenin 3-O-(3-O-acetyl-alpha-L-arabinofuranosyl)-(1 -> 3)-[alpha-L-rhamnopyranosyl-(1 -> 2)]-beta-L-arabinopyranoside, respectively. All these isolates were evaluated for inhibitory activities of FAS, which showed these isolates had inhibitory activity against FAS with IC50 values ranging from 6.69 to 204.40 mu M, comparable to the known FAS inhibitor EGCG (IC50 = 51.97 mu M). The study indicates that the hulls of Nephelium lappaceum L could be considered as potential sources of promising FAS inhibitors and the oleane-type triterpene oligoglycosides could be considered as another type of natural FAS inhibitors. (C) 2011 Elsevier Ltd. All rights reserved.
关键词Tea Epigallocatechin Gallate Antitumor-activity Food-intake Cancer Orlistat Apoptosis Rambutan Obesity Enzyme Fruit
资助信息CATAS-ITBB[110301]; Natural Science foundation of Yunnan[2008CD159]
学科领域Biochemistry & Molecular Biology ; Chemistry
DOI10.1016/j.carres.2011.04.028
收录类别sci
语种英语
WOS记录号WOS:000292858600005
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5381
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China
2.Chinese Acad Sci, Coll Life Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci Kunming, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
4.Anhui Univ, Sch Life Sci, Hefei 230039, Peoples R China
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Zhao, You-Xing,Liang, Wen-Juan,Fan, Hui-Jin,et al. Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L.[J]. CARBOHYDRATE RESEARCH,2011,346(11):1302-1306.
APA Zhao, You-Xing.,Liang, Wen-Juan.,Fan, Hui-Jin.,Ma, Qing-Yun.,Tian, Wei-Xi.,...&Ma, Xiao-Feng.(2011).Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L..CARBOHYDRATE RESEARCH,346(11),1302-1306.
MLA Zhao, You-Xing,et al."Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L.".CARBOHYDRATE RESEARCH 346.11(2011):1302-1306.
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