Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis
Shen, Yan2; Luo, Qiong2; Xu, Huimin1; Gong, Fangyuan2; Zhou, Xiaobin2; Sun, Yang2; Wu, Xuefeng2; Liu, Wen2; Zeng, Guangzhi1; Tan, Ninghua1; Xu, Qiang2
Corresponding AuthorTan, NH (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2011-08-01
Source PublicationBIOCHEMICAL PHARMACOLOGY
ISSN0006-2952
Volume82Issue:3Pages:260-268
AbstractFacilitating T-cell apoptosis is implicated as an effective therapeutic strategy for treatment of T cell-mediated disease, including inflammatory bowel disease. Here, we report that astin C, a plant cyclopeptide isolated from the roots of Aster tataricus (Compositae), induced apoptosis of activated T cells in a mitochondria-dependent but Fas-independent manner in that such activity was still observed in T cells from Fas-mutated MRL(lpr/lpr) mice. Although caspase 8 was not activated, astin C treatment led to the cleavage of caspase 9 and caspase 3, the upregulation of Bad protein expression as well as release of cytochrome c in activated T cells. Astin C did not induce the expression of GRP78 and GADD153, excluding involvement of endoplasmic reticulum stress-mediated pathway. Moreover, oral administration of astin C protected mice against TNBS-induced colonic inflammation, as assessed by a reduced colonic weight/length ratio and histological scoring. Administering astin C significantly decreased serum levels of TNF-alpha, IL-4 and IL-17, accompanied with the induction of apoptosis in activated T cells in vivo. The results demonstrate, for the first time, the ability of astin C to induce apoptosis in activated T cells and its potential use in the treatment of colonic inflammation. (C) 2011 Elsevier Inc. All rights reserved.
KeywordAstin c t Lymphocyte Apoptosis Mitochondria Colitis
Subject AreaPharmacology & Pharmacy
DOI10.1016/j.bcp.2011.04.013
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000292371400008
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/5315
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Sch Life Sci, Nanjing 210093, Peoples R China
Recommended Citation
GB/T 7714
Shen, Yan,Luo, Qiong,Xu, Huimin,et al. Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis[J]. BIOCHEMICAL PHARMACOLOGY,2011,82(3):260-268.
APA Shen, Yan.,Luo, Qiong.,Xu, Huimin.,Gong, Fangyuan.,Zhou, Xiaobin.,...&Xu, Qiang.(2011).Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis.BIOCHEMICAL PHARMACOLOGY,82(3),260-268.
MLA Shen, Yan,et al."Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis".BIOCHEMICAL PHARMACOLOGY 82.3(2011):260-268.
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