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题名: Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis
作者: Shen, Yan2; Luo, Qiong2; Xu, Huimin1; Gong, Fangyuan2; Zhou, Xiaobin2; Sun, Yang2; Wu, Xuefeng2; Liu, Wen2; Zeng, Guangzhi1; Tan, Ninghua1; Xu, Qiang2
刊名: BIOCHEMICAL PHARMACOLOGY
关键词: Astin C ; T lymphocyte ; Apoptosis ; Mitochondria ; Colitis
英文摘要: Facilitating T-cell apoptosis is implicated as an effective therapeutic strategy for treatment of T cell-mediated disease, including inflammatory bowel disease. Here, we report that astin C, a plant cyclopeptide isolated from the roots of Aster tataricus (Compositae), induced apoptosis of activated T cells in a mitochondria-dependent but Fas-independent manner in that such activity was still observed in T cells from Fas-mutated MRL(lpr/lpr) mice. Although caspase 8 was not activated, astin C treatment led to the cleavage of caspase 9 and caspase 3, the upregulation of Bad protein expression as well as release of cytochrome c in activated T cells. Astin C did not induce the expression of GRP78 and GADD153, excluding involvement of endoplasmic reticulum stress-mediated pathway. Moreover, oral administration of astin C protected mice against TNBS-induced colonic inflammation, as assessed by a reduced colonic weight/length ratio and histological scoring. Administering astin C significantly decreased serum levels of TNF-alpha, IL-4 and IL-17, accompanied with the induction of apoptosis in activated T cells in vivo. The results demonstrate, for the first time, the ability of astin C to induce apoptosis in activated T cells and its potential use in the treatment of colonic inflammation. (C) 2011 Elsevier Inc. All rights reserved.
出版日期: 2011-08-01
卷号: 82, 期号:3, 页码:260-268
DOI标识: 10.1016/j.bcp.2011.04.013
语种: 英语
收录类别: SCI
学科分类: Pharmacology & Pharmacy
ISSN号: 0006-2952
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5315
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Sch Life Sci, Nanjing 210093, Peoples R China

Recommended Citation:
Shen, Y; Luo, Q; Xu, HM; Gong, FY; Zhou, XB; Sun, Y; Wu, XF; Liu, W; Zeng, GZ; Tan, NH; Xu, Q.Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis,BIOCHEMICAL PHARMACOLOGY,2011,82(3):260-268
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