Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis
Shen, Yan2; Luo, Qiong2; Xu, Huimin1; Gong, Fangyuan2; Zhou, Xiaobin2; Sun, Yang2; Wu, Xuefeng2; Liu, Wen2; Zeng, Guangzhi1; Tan, Ninghua1; Xu, Qiang2
2011-08-01
发表期刊BIOCHEMICAL PHARMACOLOGY
ISSN0006-2952
卷号82期号:3页码:260-268
摘要Facilitating T-cell apoptosis is implicated as an effective therapeutic strategy for treatment of T cell-mediated disease, including inflammatory bowel disease. Here, we report that astin C, a plant cyclopeptide isolated from the roots of Aster tataricus (Compositae), induced apoptosis of activated T cells in a mitochondria-dependent but Fas-independent manner in that such activity was still observed in T cells from Fas-mutated MRL(lpr/lpr) mice. Although caspase 8 was not activated, astin C treatment led to the cleavage of caspase 9 and caspase 3, the upregulation of Bad protein expression as well as release of cytochrome c in activated T cells. Astin C did not induce the expression of GRP78 and GADD153, excluding involvement of endoplasmic reticulum stress-mediated pathway. Moreover, oral administration of astin C protected mice against TNBS-induced colonic inflammation, as assessed by a reduced colonic weight/length ratio and histological scoring. Administering astin C significantly decreased serum levels of TNF-alpha, IL-4 and IL-17, accompanied with the induction of apoptosis in activated T cells in vivo. The results demonstrate, for the first time, the ability of astin C to induce apoptosis in activated T cells and its potential use in the treatment of colonic inflammation. (C) 2011 Elsevier Inc. All rights reserved.
关键词Astin c t Lymphocyte Apoptosis Mitochondria Colitis
资助信息National Natural Science Foundation of China[90913023, 30973920, 30973546]; Science Fund for Creative Research Groups[30821006]; Natural Science Foundation of Jiangsu Province[BK2008022, BK2009238]
学科领域Pharmacology & Pharmacy
DOI10.1016/j.bcp.2011.04.013
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Pharmacology & Pharmacy
WOS记录号WOS:000292371400008
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5315
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Sch Life Sci, Nanjing 210093, Peoples R China
推荐引用方式
GB/T 7714
Shen, Yan,Luo, Qiong,Xu, Huimin,et al. Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis[J]. BIOCHEMICAL PHARMACOLOGY,2011,82(3):260-268.
APA Shen, Yan.,Luo, Qiong.,Xu, Huimin.,Gong, Fangyuan.,Zhou, Xiaobin.,...&Xu, Qiang.(2011).Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis.BIOCHEMICAL PHARMACOLOGY,82(3),260-268.
MLA Shen, Yan,et al."Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis".BIOCHEMICAL PHARMACOLOGY 82.3(2011):260-268.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
201204050017.pdf(1203KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Shen, Yan]的文章
[Luo, Qiong]的文章
[Xu, Huimin]的文章
百度学术
百度学术中相似的文章
[Shen, Yan]的文章
[Luo, Qiong]的文章
[Xu, Huimin]的文章
必应学术
必应学术中相似的文章
[Shen, Yan]的文章
[Luo, Qiong]的文章
[Xu, Huimin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。