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Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection
Pei, Ying2; Xiang, Yang-Fei2; Chen, Jia-Nan3; Lu, Chun-Hua4; Hao, Jing5; Du, Qian2; Lai, Chi-choi2; Qu, Chang2; Li, Shen2; Ju, Huai-Qiang2; Ren, Zhe2; Liu, Qiu-Ying2; Xiong, Sheng2; Qian, Chui-Wen2; Zeng, Fan-Li2; Zhang, Pei-Zhuo6; Yang, Chong-Ren1; Zhang, Ying-Jun1; Xu, Jun7; Kitazato, Kaio8; Wang, Yi-Fei2
Corresponding AuthorZhang, YJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2011
Source PublicationANTIVIRAL RESEARCH
ISSN0166-3542
Volume89Issue:1Pages:98-108
AbstractTo investigate the anti-herpesvirus mechanism of pentagalloylglucose (PGG), we compared the proteomic changes between herpes simplex virus type 1 (HSV-1) infected MRC-5 cells with or without PGG-treatment, and between non-infected MRC-5 cells with or without PGG-treatment by 2-DE and MS-based analysis. Differentially expressed cellular proteins were mainly involved with actin cytoskeleton regulation. Significantly, PGG can down-regulate cofilin1, a key regulator of actin cytoskeleton dynamics. PGG can inhibit HSV-1-induced rearrangements of actin cytoskeleton which is important for infectivity. Furthermore, cofilin1 knockdown by siRNA also inhibited the HSV-1-induced actin-skeleton rearrangements. Both PGG-treatment and cofilin1 knockdown can reduce HSV-1 DNA, mRNA, protein synthesis and virus yields. Altogether, the results suggested that down-regulating cofilin1 plays a role in PGG inhibiting HSV-1 infection. PGG may be a promising anti-herpesvirus agent for drug development. (C) 2010 Elsevier B.V. All rights reserved.
KeywordHerpes Simplex Virus Type 1 Pentagalloylglucose Two-dimensional Gel Electrophoresis Actin Cytoskeleton Cofilin1
Subject AreaPharmacology & Pharmacy ; Virology
DOI10.1016/j.antiviral.2010.11.012
Indexed BySCI
Language英语
WOS IDWOS:000287065100013
Citation statistics
Cited Times:35[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/5213
Collection资源植物与生物技术所级重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
3.Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China
4.Jinan Univ, Inst Life & Hlth Engn, Guangzhou 510632, Guangdong, Peoples R China
5.Chinese Acad Sci, S China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China
6.Shanghai GenePharma Co Ltd, Shanghai 201203, Peoples R China
7.Sun Yet Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
8.Nagasaki Univ, Lab Mol Biol Infect Agents, Dept Mol Microbiol & Immunol, Grad Sch Biomed Sci, Nagasaki 852, Japan
Recommended Citation
GB/T 7714
Pei, Ying,Xiang, Yang-Fei,Chen, Jia-Nan,et al. Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection[J]. ANTIVIRAL RESEARCH,2011,89(1):98-108.
APA Pei, Ying.,Xiang, Yang-Fei.,Chen, Jia-Nan.,Lu, Chun-Hua.,Hao, Jing.,...&Wang, Yi-Fei.(2011).Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection.ANTIVIRAL RESEARCH,89(1),98-108.
MLA Pei, Ying,et al."Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection".ANTIVIRAL RESEARCH 89.1(2011):98-108.
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