KIB OpenIR  > 资源植物与生物技术所级重点实验室
Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection
Pei, Ying2; Xiang, Yang-Fei2; Chen, Jia-Nan3; Lu, Chun-Hua4; Hao, Jing5; Du, Qian2; Lai, Chi-choi2; Qu, Chang2; Li, Shen2; Ju, Huai-Qiang2; Ren, Zhe2; Liu, Qiu-Ying2; Xiong, Sheng2; Qian, Chui-Wen2; Zeng, Fan-Li2; Zhang, Pei-Zhuo6; Yang, Chong-Ren1; Zhang, Ying-Jun1; Xu, Jun7; Kitazato, Kaio8; Wang, Yi-Fei2
Corresponding AuthorZhang, YJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2011
Source PublicationANTIVIRAL RESEARCH
ISSN0166-3542
Volume89Issue:1Pages:98-108
AbstractTo investigate the anti-herpesvirus mechanism of pentagalloylglucose (PGG), we compared the proteomic changes between herpes simplex virus type 1 (HSV-1) infected MRC-5 cells with or without PGG-treatment, and between non-infected MRC-5 cells with or without PGG-treatment by 2-DE and MS-based analysis. Differentially expressed cellular proteins were mainly involved with actin cytoskeleton regulation. Significantly, PGG can down-regulate cofilin1, a key regulator of actin cytoskeleton dynamics. PGG can inhibit HSV-1-induced rearrangements of actin cytoskeleton which is important for infectivity. Furthermore, cofilin1 knockdown by siRNA also inhibited the HSV-1-induced actin-skeleton rearrangements. Both PGG-treatment and cofilin1 knockdown can reduce HSV-1 DNA, mRNA, protein synthesis and virus yields. Altogether, the results suggested that down-regulating cofilin1 plays a role in PGG inhibiting HSV-1 infection. PGG may be a promising anti-herpesvirus agent for drug development. (C) 2010 Elsevier B.V. All rights reserved.
KeywordHerpes Simplex Virus Type 1 Pentagalloylglucose Two-dimensional Gel Electrophoresis Actin Cytoskeleton Cofilin1
Subject AreaPharmacology & Pharmacy ; Virology
DOI10.1016/j.antiviral.2010.11.012
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Virology
WOS SubjectPharmacology & Pharmacy ; Virology
WOS IDWOS:000287065100013
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/5213
Collection资源植物与生物技术所级重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
3.Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China
4.Jinan Univ, Inst Life & Hlth Engn, Guangzhou 510632, Guangdong, Peoples R China
5.Chinese Acad Sci, S China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China
6.Shanghai GenePharma Co Ltd, Shanghai 201203, Peoples R China
7.Sun Yet Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
8.Nagasaki Univ, Lab Mol Biol Infect Agents, Dept Mol Microbiol & Immunol, Grad Sch Biomed Sci, Nagasaki 852, Japan
Recommended Citation
GB/T 7714
Pei, Ying,Xiang, Yang-Fei,Chen, Jia-Nan,et al. Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection[J]. ANTIVIRAL RESEARCH,2011,89(1):98-108.
APA Pei, Ying.,Xiang, Yang-Fei.,Chen, Jia-Nan.,Lu, Chun-Hua.,Hao, Jing.,...&Wang, Yi-Fei.(2011).Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection.ANTIVIRAL RESEARCH,89(1),98-108.
MLA Pei, Ying,et al."Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection".ANTIVIRAL RESEARCH 89.1(2011):98-108.
Files in This Item: Download All
File Name/Size DocType Version Access License
201204090039.pdf(1708KB) 开放获取--View Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Pei, Ying]'s Articles
[Xiang, Yang-Fei]'s Articles
[Chen, Jia-Nan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Pei, Ying]'s Articles
[Xiang, Yang-Fei]'s Articles
[Chen, Jia-Nan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Pei, Ying]'s Articles
[Xiang, Yang-Fei]'s Articles
[Chen, Jia-Nan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 201204090039.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.