Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection
Pei, Ying2; Xiang, Yang-Fei2; Chen, Jia-Nan3; Lu, Chun-Hua4; Hao, Jing5; Du, Qian2; Lai, Chi-choi2; Qu, Chang2; Li, Shen2; Ju, Huai-Qiang2; Ren, Zhe2; Liu, Qiu-Ying2; Xiong, Sheng2; Qian, Chui-Wen2; Zeng, Fan-Li2; Zhang, Pei-Zhuo6; Yang, Chong-Ren1; Zhang, Ying-Jun1; Xu, Jun7; Kitazato, Kaio8; Wang, Yi-Fei2
2011
发表期刊ANTIVIRAL RESEARCH
ISSN0166-3542
卷号89期号:1页码:98-108
摘要To investigate the anti-herpesvirus mechanism of pentagalloylglucose (PGG), we compared the proteomic changes between herpes simplex virus type 1 (HSV-1) infected MRC-5 cells with or without PGG-treatment, and between non-infected MRC-5 cells with or without PGG-treatment by 2-DE and MS-based analysis. Differentially expressed cellular proteins were mainly involved with actin cytoskeleton regulation. Significantly, PGG can down-regulate cofilin1, a key regulator of actin cytoskeleton dynamics. PGG can inhibit HSV-1-induced rearrangements of actin cytoskeleton which is important for infectivity. Furthermore, cofilin1 knockdown by siRNA also inhibited the HSV-1-induced actin-skeleton rearrangements. Both PGG-treatment and cofilin1 knockdown can reduce HSV-1 DNA, mRNA, protein synthesis and virus yields. Altogether, the results suggested that down-regulating cofilin1 plays a role in PGG inhibiting HSV-1 infection. PGG may be a promising anti-herpesvirus agent for drug development. (C) 2010 Elsevier B.V. All rights reserved.
关键词Herpes Simplex Virus Type 1 Pentagalloylglucose Two-dimensional Gel Electrophoresis Actin Cytoskeleton Cofilin1
资助信息National Science Foundation of China[U0632010]; State Key Laboratory of Phytochemistry and Plant Resources in West China; Kunming Institute of Botany; Chinese Academy of Sciences[P2008-KF07, P2008-ZZ08]; Ministry of Education (MOE); Fundamental Research Funds for the Central Universities
学科领域Pharmacology & Pharmacy ; Virology
DOI10.1016/j.antiviral.2010.11.012
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Virology
WOS类目Pharmacology & Pharmacy ; Virology
WOS记录号WOS:000287065100013
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5213
专题资源植物与生物技术所级重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
3.Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China
4.Jinan Univ, Inst Life & Hlth Engn, Guangzhou 510632, Guangdong, Peoples R China
5.Chinese Acad Sci, S China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China
6.Shanghai GenePharma Co Ltd, Shanghai 201203, Peoples R China
7.Sun Yet Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
8.Nagasaki Univ, Lab Mol Biol Infect Agents, Dept Mol Microbiol & Immunol, Grad Sch Biomed Sci, Nagasaki 852, Japan
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Pei, Ying,Xiang, Yang-Fei,Chen, Jia-Nan,et al. Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection[J]. ANTIVIRAL RESEARCH,2011,89(1):98-108.
APA Pei, Ying.,Xiang, Yang-Fei.,Chen, Jia-Nan.,Lu, Chun-Hua.,Hao, Jing.,...&Wang, Yi-Fei.(2011).Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection.ANTIVIRAL RESEARCH,89(1),98-108.
MLA Pei, Ying,et al."Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection".ANTIVIRAL RESEARCH 89.1(2011):98-108.
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