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题名: Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection
作者: Pei, Ying2; Xiang, Yang-Fei2; Chen, Jia-Nan3; Lu, Chun-Hua4; Hao, Jing5; Du, Qian2; Lai, Chi-choi2; Qu, Chang2; Li, Shen2; Ju, Huai-Qiang2; Ren, Zhe2; Liu, Qiu-Ying2; Xiong, Sheng2; Qian, Chui-Wen2; Zeng, Fan-Li2; Zhang, Pei-Zhuo6; Yang, Chong-Ren1; null(张颖君)1; Xu, Jun7; Kitazato, Kaio8; Wang, Yi-Fei2
刊名: ANTIVIRAL RESEARCH
关键词: Herpes simplex virus type 1 ; Pentagalloylglucose ; Two-dimensional gel electrophoresis ; Actin cytoskeleton ; Cofilin1
英文摘要: To investigate the anti-herpesvirus mechanism of pentagalloylglucose (PGG), we compared the proteomic changes between herpes simplex virus type 1 (HSV-1) infected MRC-5 cells with or without PGG-treatment, and between non-infected MRC-5 cells with or without PGG-treatment by 2-DE and MS-based analysis. Differentially expressed cellular proteins were mainly involved with actin cytoskeleton regulation. Significantly, PGG can down-regulate cofilin1, a key regulator of actin cytoskeleton dynamics. PGG can inhibit HSV-1-induced rearrangements of actin cytoskeleton which is important for infectivity. Furthermore, cofilin1 knockdown by siRNA also inhibited the HSV-1-induced actin-skeleton rearrangements. Both PGG-treatment and cofilin1 knockdown can reduce HSV-1 DNA, mRNA, protein synthesis and virus yields. Altogether, the results suggested that down-regulating cofilin1 plays a role in PGG inhibiting HSV-1 infection. PGG may be a promising anti-herpesvirus agent for drug development. (C) 2010 Elsevier B.V. All rights reserved.
出版日期: 2011
卷号: 89, 期号:1, 页码:98-108
DOI标识: 10.1016/j.antiviral.2010.11.012
语种: 英语
收录类别: SCI
学科分类: Pharmacology & Pharmacy; Virology
ISSN号: 0166-3542
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5213
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
3.Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China
4.Jinan Univ, Inst Life & Hlth Engn, Guangzhou 510632, Guangdong, Peoples R China
5.Chinese Acad Sci, S China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China
6.Shanghai GenePharma Co Ltd, Shanghai 201203, Peoples R China
7.Sun Yet Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
8.Nagasaki Univ, Lab Mol Biol Infect Agents, Dept Mol Microbiol & Immunol, Grad Sch Biomed Sci, Nagasaki 852, Japan

Recommended Citation:
Pei, Y; Xiang, YF; Chen, JN; Lu, CH; Hao, J; Du, QA; Lai, CC; Qu, C; Li, S; Ju, HQ; Ren, Z; Liu, QY; Xiong, S; Qian, CW; Zeng, FL; Zhang, PZ; Yang, CR; Zhang, YJ; Xu, J; Kitazato, K; Wang, YF.Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection,ANTIVIRAL RESEARCH,2011,89(1):98-108
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