Progress of Cyclotides in Plants

	Progress of Cyclotides in Plants
	Tang Jun 1,2; Tan Ninghua 1
	2010-04-01
发表期刊	PROGRESS IN CHEMISTRY
卷号	22 期号:4 页码:677-683
摘要	Cyclotides are a family of plant-derived macrocyclic peptides, which are formed by 28-37 amino acid residues and contain three disulfide bonds and the unique protein structural motif termed cyclic cystine knot. For their unique structures and various bioactivities, such as uterotonic, hemolytic, cytotoxic and anti-bacterial activities, and stability to resist thermal, acidic and proteolytic degradation, cyclotides can be used as a peptide-based combinational template and carrier for drug design, and attract more attentions from scientists. Now over 100 cyclotides have been isolated from about 30 species of Violaceae, Rubiaceae and Cucurbitaceae. Most contributions on cyclotides have been achieved by the research groups in Australia, Sweden and USA. Our lab is also investigating on cyclotides. This paper introduces cyclotides' research history, methods for extraction, isolation and detection, structural determination and classification, homological analysis of sequences, synthesis and biosynthesis, bioactivity and so on.
关键词	Cyclotides Plants Cyclic Cystine Knot
学科领域	Chemistry, Multidisciplinary
收录类别	SCI
语种	英语
WOS记录号	WOS:000276929300014
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/5180
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Tang Jun,Tan Ninghua. Progress of Cyclotides in Plants[J]. PROGRESS IN CHEMISTRY,2010,22(4):677-683.
APA	Tang Jun,&Tan Ninghua.(2010).Progress of Cyclotides in Plants.PROGRESS IN CHEMISTRY,22(4),677-683.
MLA	Tang Jun,et al."Progress of Cyclotides in Plants".PROGRESS IN CHEMISTRY 22.4(2010):677-683.

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