Progress of Cyclotides in Plants
Tang Jun1,2; Tan Ninghua1
2010-04-01
发表期刊PROGRESS IN CHEMISTRY
卷号22期号:4页码:677-683
摘要Cyclotides are a family of plant-derived macrocyclic peptides, which are formed by 28-37 amino acid residues and contain three disulfide bonds and the unique protein structural motif termed cyclic cystine knot. For their unique structures and various bioactivities, such as uterotonic, hemolytic, cytotoxic and anti-bacterial activities, and stability to resist thermal, acidic and proteolytic degradation, cyclotides can be used as a peptide-based combinational template and carrier for drug design, and attract more attentions from scientists. Now over 100 cyclotides have been isolated from about 30 species of Violaceae, Rubiaceae and Cucurbitaceae. Most contributions on cyclotides have been achieved by the research groups in Australia, Sweden and USA. Our lab is also investigating on cyclotides. This paper introduces cyclotides' research history, methods for extraction, isolation and detection, structural determination and classification, homological analysis of sequences, synthesis and biosynthesis, bioactivity and so on.
关键词Cyclotides Plants Cyclic Cystine Knot
学科领域Chemistry, Multidisciplinary
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000276929300014
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5180
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Tang Jun,Tan Ninghua. Progress of Cyclotides in Plants[J]. PROGRESS IN CHEMISTRY,2010,22(4):677-683.
APA Tang Jun,&Tan Ninghua.(2010).Progress of Cyclotides in Plants.PROGRESS IN CHEMISTRY,22(4),677-683.
MLA Tang Jun,et al."Progress of Cyclotides in Plants".PROGRESS IN CHEMISTRY 22.4(2010):677-683.
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