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题名: Progress of Cyclotides in Plants
作者: Tang Jun1, 2; Tan Ninghua1
刊名: PROGRESS IN CHEMISTRY
关键词: cyclotides ; plants ; cyclic cystine knot
英文摘要: Cyclotides are a family of plant-derived macrocyclic peptides, which are formed by 28-37 amino acid residues and contain three disulfide bonds and the unique protein structural motif termed cyclic cystine knot. For their unique structures and various bioactivities, such as uterotonic, hemolytic, cytotoxic and anti-bacterial activities, and stability to resist thermal, acidic and proteolytic degradation, cyclotides can be used as a peptide-based combinational template and carrier for drug design, and attract more attentions from scientists. Now over 100 cyclotides have been isolated from about 30 species of Violaceae, Rubiaceae and Cucurbitaceae. Most contributions on cyclotides have been achieved by the research groups in Australia, Sweden and USA. Our lab is also investigating on cyclotides. This paper introduces cyclotides' research history, methods for extraction, isolation and detection, structural determination and classification, homological analysis of sequences, synthesis and biosynthesis, bioactivity and so on.
出版日期: 2010-04-01
卷号: 22, 期号:4, 页码:677-683
语种: 英语
收录类别: SCI
学科分类: Chemistry, Multidisciplinary
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5180
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

Recommended Citation:
Tang, J; Tan, NH.Progress of Cyclotides in Plants,PROGRESS IN CHEMISTRY,2010,22(4):677-683
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