The role of MC1R gene in buffalo coat color
Miao YongWang1,2; Wu GuiSheng3; Wang Lei2; Li DaLin4; Tang ShouKun5; Liang JianPing2; Mao HuaMing2; Luo HuaiRong3; Zhang YaPing1,6
2010-02-01
Source PublicationSCIENCE CHINA-LIFE SCIENCES
Volume53Issue:2Pages:267-272
AbstractMelanocortin-1 receptor (MC1R) plays a major role in pigmentation in many species. To investigate if the MC1R gene is associated with coat color in water buffalo, the coding region of MC1R gene of 216 buffalo samples was sequenced, which included 49 black river buffalo (Murrah and Nili-Ravi), 136 swamp buffalo (Dehong, Diandongnan, Dechang, Guizhou, and Xilin) with white and gray body, and 31 hybrid offspring of river buffalo Nili-Ravi (or Murrah) and swamp buffalo. Among the three variation sites found, SNP684 was synonymous, while SNP310 and SNP384 were nonsynonymous, leading to p.S104G and p.I128M changes, respectively. Only Individuals carrying homozygote E-BR/E-BR were black. The genotype and phenotype analysis of the hybrid offspring of black river buffalo and gray swamp buffalo further revealed that the river buffalo type allele E-BR or the allele carrying the amino acid p.104S was important for the full function of MC1R. The in silico functional analysis showed that the amino acid substitutions p.G104S and p.M128I had significant impact on the function of MC1R. Above results indicate that the allele E-BR or the allele carrying the amino acid p.104S was associated with the black coat color in buffalo.
KeywordBuffalo Coat Color Mc1r
Subject AreaBiology
DOI10.1007/s11427-010-0026-3
Indexed BySCI
Language英语
WOS IDWOS:000276438100017
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/5178
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Yunnan Univ, Lab Conservat & Utilizat Bioresource, Kunming 650091, Peoples R China
2.Yunnan Agr Univ, Fac Anim Sci & Technol, Kunming 650201, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
4.Yunnan Inst Buffalo Sci & Technol, Kunming 650021, Peoples R China
5.Anim Husb & Vet Stn Luxi City, Luxi 678400, Peoples R China
6.Chinese Acad Sci, State Key Lab Genet Resources & Evolut, Kunming Inst Zool, Kunming 650223, Peoples R China
Recommended Citation
GB/T 7714
Miao YongWang,Wu GuiSheng,Wang Lei,et al. The role of MC1R gene in buffalo coat color[J]. SCIENCE CHINA-LIFE SCIENCES,2010,53(2):267-272.
APA Miao YongWang.,Wu GuiSheng.,Wang Lei.,Li DaLin.,Tang ShouKun.,...&Zhang YaPing.(2010).The role of MC1R gene in buffalo coat color.SCIENCE CHINA-LIFE SCIENCES,53(2),267-272.
MLA Miao YongWang,et al."The role of MC1R gene in buffalo coat color".SCIENCE CHINA-LIFE SCIENCES 53.2(2010):267-272.
Files in This Item: Download All
File Name/Size DocType Version Access License
201203210002.pdf(1385KB) 开放获取--View Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Miao YongWang]'s Articles
[Wu GuiSheng]'s Articles
[Wang Lei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Miao YongWang]'s Articles
[Wu GuiSheng]'s Articles
[Wang Lei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Miao YongWang]'s Articles
[Wu GuiSheng]'s Articles
[Wang Lei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 201203210002.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.