The role of MC1R gene in buffalo coat color
Miao YongWang1,2; Wu GuiSheng3; Wang Lei2; Li DaLin4; Tang ShouKun5; Liang JianPing2; Mao HuaMing2; Luo HuaiRong3; Zhang YaPing1,6
2010-02-01
发表期刊SCIENCE CHINA-LIFE SCIENCES
卷号53期号:2页码:267-272
摘要Melanocortin-1 receptor (MC1R) plays a major role in pigmentation in many species. To investigate if the MC1R gene is associated with coat color in water buffalo, the coding region of MC1R gene of 216 buffalo samples was sequenced, which included 49 black river buffalo (Murrah and Nili-Ravi), 136 swamp buffalo (Dehong, Diandongnan, Dechang, Guizhou, and Xilin) with white and gray body, and 31 hybrid offspring of river buffalo Nili-Ravi (or Murrah) and swamp buffalo. Among the three variation sites found, SNP684 was synonymous, while SNP310 and SNP384 were nonsynonymous, leading to p.S104G and p.I128M changes, respectively. Only Individuals carrying homozygote E-BR/E-BR were black. The genotype and phenotype analysis of the hybrid offspring of black river buffalo and gray swamp buffalo further revealed that the river buffalo type allele E-BR or the allele carrying the amino acid p.104S was important for the full function of MC1R. The in silico functional analysis showed that the amino acid substitutions p.G104S and p.M128I had significant impact on the function of MC1R. Above results indicate that the allele E-BR or the allele carrying the amino acid p.104S was associated with the black coat color in buffalo.
关键词Buffalo Coat Color Mc1r
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5178
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ, Lab Conservat & Utilizat Bioresource, Kunming 650091, Peoples R China
2.Yunnan Agr Univ, Fac Anim Sci & Technol, Kunming 650201, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
4.Yunnan Inst Buffalo Sci & Technol, Kunming 650021, Peoples R China
5.Anim Husb & Vet Stn Luxi City, Luxi 678400, Peoples R China
6.Chinese Acad Sci, State Key Lab Genet Resources & Evolut, Kunming Inst Zool, Kunming 650223, Peoples R China
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Miao YongWang,Wu GuiSheng,Wang Lei,et al. The role of MC1R gene in buffalo coat color[J]. SCIENCE CHINA-LIFE SCIENCES,2010,53(2):267-272.
APA Miao YongWang.,Wu GuiSheng.,Wang Lei.,Li DaLin.,Tang ShouKun.,...&Zhang YaPing.(2010).The role of MC1R gene in buffalo coat color.SCIENCE CHINA-LIFE SCIENCES,53(2),267-272.
MLA Miao YongWang,et al."The role of MC1R gene in buffalo coat color".SCIENCE CHINA-LIFE SCIENCES 53.2(2010):267-272.
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