Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum
Guo, Yi1; Zhang, Na1; Chen, Chunmei1; Huang, Jinfeng1; Li, Xiao-Nian3; Liu, Junjun1; Zhu, Hucheng1; Tong, Qingyi1; Zhang, Jinwen2; Luo, Zengwei1; Xue, Yongbo1; Zhang, Yonghui1
2017-05-01
发表期刊JOURNAL OF NATURAL PRODUCTS
卷号80页码:1493-1504
摘要The new polyprenylated acylphloroglucinol derivatives 1-15 and the known furohyperforin (16) were isolated from the stems and leaves of Hypericum perforatum. Their structures were determined by analyses of NMR and HRESIMS data. Their absolute configurations were elucidated by a combination of electronic circular dichroism (ECD) and Rh-2(OCOCF3)(4)-induced ECD, as well as X-ray diffraction crystallography. The new hyperforatin F (9) contains a unique acetyl functionality at C-1 of the bicydo[3.3.1]nonane core. Hyperforatins G (10) and H (11) are similarly the first examples of naturally occurring [3.3.1]-type polycyclic prenylated acylphloroglucinols possessing a carbonyl functionality at C-32. The compounds were tested for their acetylcholinesterase (AChE) inhibitory activities and cytotoxic activities against a panel of human tumor cell lines. Compounds 3, 5, 6, 8, and 9 exerted moderate inhibitory activities (IC50 3.98-9.13 mu M) against AChE.
资助信息National Natural Science Foundation of China(81641129; Fundamental Research Fund for the Central Universities(2016YXMS149); Program for New Century Excellent Talents in University, State Education Ministry of China(NCET-2008-0224); National Science and Technology Project of China(2011ZX09102-004); 31370372; 81573316)
DOI10.1021/acs.jnatprod.6b01178
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000402498300032
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/51368
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
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Guo, Yi,Zhang, Na,Chen, Chunmei,et al. Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum[J]. JOURNAL OF NATURAL PRODUCTS,2017,80:1493-1504.
APA Guo, Yi.,Zhang, Na.,Chen, Chunmei.,Huang, Jinfeng.,Li, Xiao-Nian.,...&Zhang, Yonghui.(2017).Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum.JOURNAL OF NATURAL PRODUCTS,80,1493-1504.
MLA Guo, Yi,et al."Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum".JOURNAL OF NATURAL PRODUCTS 80(2017):1493-1504.
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