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题名: Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum
作者: Guo, Yi1; Zhang, Na1; Chen, Chunmei1; Huang, Jinfeng1; Li, Xiao-Nian3; Liu, Junjun1; Zhu, Hucheng1; Tong, Qingyi1; Zhang, Jinwen2; Luo, Zengwei1; Xue, Yongbo1; Zhang, Yonghui1
刊名: JOURNAL OF NATURAL PRODUCTS
英文摘要: The new polyprenylated acylphloroglucinol derivatives 1-15 and the known furohyperforin (16) were isolated from the stems and leaves of Hypericum perforatum. Their structures were determined by analyses of NMR and HRESIMS data. Their absolute configurations were elucidated by a combination of electronic circular dichroism (ECD) and Rh-2(OCOCF3)(4)-induced ECD, as well as X-ray diffraction crystallography. The new hyperforatin F (9) contains a unique acetyl functionality at C-1 of the bicydo[3.3.1]nonane core. Hyperforatins G (10) and H (11) are similarly the first examples of naturally occurring [3.3.1]-type polycyclic prenylated acylphloroglucinols possessing a carbonyl functionality at C-32. The compounds were tested for their acetylcholinesterase (AChE) inhibitory activities and cytotoxic activities against a panel of human tumor cell lines. Compounds 3, 5, 6, 8, and 9 exerted moderate inhibitory activities (IC50 3.98-9.13 mu M) against AChE.
出版日期: 2017-05-01
卷号: 80, 页码:1493-1504
DOI标识: 10.1021/acs.jnatprod.6b01178
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/51368
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China

Recommended Citation:
Guo, Yi,Zhang, Na,Chen, Chunmei,et al. Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum[J]. JOURNAL OF NATURAL PRODUCTS,2017,80:1493-1504.
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