| Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum | |
| Guo, Yi1; Zhang, Na1; Chen, Chunmei1; Huang, Jinfeng1; Li, Xiao-Nian3; Liu, Junjun1; Zhu, Hucheng1; Tong, Qingyi1; Zhang, Jinwen2; Luo, Zengwei1; Xue, Yongbo1; Zhang, Yonghui1 | |
| 2017-05-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| 卷号 | 80页码:1493-1504 |
| 摘要 | The new polyprenylated acylphloroglucinol derivatives 1-15 and the known furohyperforin (16) were isolated from the stems and leaves of Hypericum perforatum. Their structures were determined by analyses of NMR and HRESIMS data. Their absolute configurations were elucidated by a combination of electronic circular dichroism (ECD) and Rh-2(OCOCF3)(4)-induced ECD, as well as X-ray diffraction crystallography. The new hyperforatin F (9) contains a unique acetyl functionality at C-1 of the bicydo[3.3.1]nonane core. Hyperforatins G (10) and H (11) are similarly the first examples of naturally occurring [3.3.1]-type polycyclic prenylated acylphloroglucinols possessing a carbonyl functionality at C-32. The compounds were tested for their acetylcholinesterase (AChE) inhibitory activities and cytotoxic activities against a panel of human tumor cell lines. Compounds 3, 5, 6, 8, and 9 exerted moderate inhibitory activities (IC50 3.98-9.13 mu M) against AChE. |
| DOI | 10.1021/acs.jnatprod.6b01178 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000402498300032 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/51368 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Yi,Zhang, Na,Chen, Chunmei,et al. Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum[J]. JOURNAL OF NATURAL PRODUCTS,2017,80:1493-1504. |
| APA | Guo, Yi.,Zhang, Na.,Chen, Chunmei.,Huang, Jinfeng.,Li, Xiao-Nian.,...&Zhang, Yonghui.(2017).Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum.JOURNAL OF NATURAL PRODUCTS,80,1493-1504. |
| MLA | Guo, Yi,et al."Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum".JOURNAL OF NATURAL PRODUCTS 80(2017):1493-1504. |
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