Spirostanol saponins from Ypsilandra parviflora induce platelet aggregation
Lu, Ting-Xiang1,3; Shu, Tong1,2; Qin, Xu-Jie1; Ni, Wei1; Ji, Yun-Heng4; Chen, Qi-Run1,5; Khan, Afsar6; Zhao, Qing5; Liu, Hai-Yang1
2017-07-01
Source PublicationSTEROIDS
Volume123Pages:55-60
AbstractPhytochemical investigation on the whole plants of Ypsilandra parviflora led to the isolation of seven new spirostanol saponins, named ypsiparosides A-G, together with 14 known saponins. Their structures were unambiguously established based on extensive spectroscopic evidence and chemical methods. The induced rabbit platelet aggregation activities of the isolates were tested. Compounds 4, 15, and 17 showed maximal platelet aggregation rates ranging from 43 to 55% at a concentration of 300 mu g/mL. Further experiments exhibited that compounds 4, 15, and 17 possessed EC50 values of 642.9, 95.3, and 300.8 mu g/mL, respectively.
KeywordYpsilandra Parviflora Liliaceae Spirostanol Saponins Ypsiparosides A-g Induced Platelet Aggregation Activity
DOI10.1016/j.steroids.2017.05.004
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS IDWOS:000403131400008
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/51359
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Qiannan Med Coll Nationalities, Duyun 558000, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Biodivers & Biogeog East Asia, Kunming 650201, Peoples R China
5.Yunnan Univ TCM, Coll Tradit Chinese Med, Kunming 650500, Peoples R China
6.COMSATS Inst Informat Technol, Dept Chem, Abbottabad 22060, Pakistan
Recommended Citation
GB/T 7714
Lu, Ting-Xiang,Shu, Tong,Qin, Xu-Jie,et al. Spirostanol saponins from Ypsilandra parviflora induce platelet aggregation[J]. STEROIDS,2017,123:55-60.
APA Lu, Ting-Xiang.,Shu, Tong.,Qin, Xu-Jie.,Ni, Wei.,Ji, Yun-Heng.,...&Liu, Hai-Yang.(2017).Spirostanol saponins from Ypsilandra parviflora induce platelet aggregation.STEROIDS,123,55-60.
MLA Lu, Ting-Xiang,et al."Spirostanol saponins from Ypsilandra parviflora induce platelet aggregation".STEROIDS 123(2017):55-60.
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