| Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis | |
Dai, Zhi1,3; Li, Shi-Rong1,3; Zhu, Pei-Feng2,3; Liu, Lu2,3; Wang, Bei2,3; Liu, Ya-Ping2; Luo, Xiao-Dong2 ; Zhao, Xu-Dong1
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| 2017-07-01 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| 卷号 | 27页码:2863-2867 |
| 摘要 | Glioblastoma multiform (GBM) is a highly aggressive brain tumor with poor life expectancy, and glioma stem cells (GSCs) are a small population of tumor cells existed in GBM, in which GSCs response to drive GBM recurrence, invasion and contribute to the anti-cancer resistance. GSCs have been identified and developed as a therapeutic target for GBM and can be used in drugs screening. Isocostunolide is a natural sesquiterpenoid and contained abundant resource in medicinal plants, but the anti-cancer efficacies of it against GSCs are still unexplored. In this investigation, the anti-tumor activity of isocostunolide against GSCs was investigated and the result demonstrated that it inhibited the growth of GSCs (GSC-3#, GSC-12#, GSC-18#) significantly with an IC50 value of 2.80 mu g/ml, 2.61 mu g/ml, 1.07 mu g/ml, respectively. In further mechanism study, isocostunolide inhibited GSCs cell proliferation, induced GSCs apoptosis significantly, as well as increased the proportion of the cleavage of caspase-3. The result suggested that isocostunolide induced GSCs apoptosis via the caspase dependent apoptotic pathway. Moreover, isocostunolide damaged GSCs colony formation capacity significantly and exhibited the anti-cancer efficacy against GSCs in vitro. (C) 2017 Published by Elsevier Ltd. |
| 关键词 | Isocostunolide Glioma Stem Cells Cell Proliferation Apoptosis Colony Formation |
| DOI | 10.1016/j.bmcl.2017.04.075 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000402470600005 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/51348 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Bioact Peptides Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, 21 QingSong Rd, Kunming 650223, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 LanHei Rd, Kunming 650201, Yunnan Province, Peoples R China 3.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dai, Zhi,Li, Shi-Rong,Zhu, Pei-Feng,et al. Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27:2863-2867. |
| APA | Dai, Zhi.,Li, Shi-Rong.,Zhu, Pei-Feng.,Liu, Lu.,Wang, Bei.,...&Zhao, Xu-Dong.(2017).Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,27,2863-2867. |
| MLA | Dai, Zhi,et al."Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27(2017):2863-2867. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| dai2017.pdf（2209KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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