| Iridoids and bis-iridoids from Patrinia scabiosaefolia | |
Liu, Zhen-Hua1,2; Hou, Bo1,2; Yang, Liu1; Ma, Rui-Jing1,2; Li, Jin-Yu1,2; Hu, Jiang-Miao1 ; Zhou, Jun1
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| 2017 | |
| 发表期刊 | RSC ADVANCES
 |
| 卷号 | 7期号:40页码:24940-24949 |
| 摘要 | Ten new iridoids, patriscabioins A-J (1-10), and three unique bis-iridoids, patriscabiobisins A-C (11-13), together with seven known analogues, have been identified from whole plants of Patrinia scabiosaefolia. Compounds 1 to 8 are a series of 5,6-dihydrovaltrate hydrins with unique substituent groups in the Valerianaceae family such as isovaleryl and 3-methylcrotonyl. Furthermore, compounds 11 and 12 are the first reported bis-iridoids with two units connected by a 1,3-dioxane group, whereas compound 13 is linked by an ether bond between two units. The structures of all the compounds were established on the basis of extensive spectroscopic analysis as well as experimental and calculated ECD spectra. Compounds 1 and 3 showed moderate inhibitory activities on AChE with IC50 values of 37.6 and 10.5 mu M, respectively. Moreover, compounds 1, 3, and 5 also showed moderate cytotoxic activity against HL-60, with IC50 values ranging from 1.2 to 27.6 mu M. |
| DOI | 10.1039/c7ra03345a |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000401525700049 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/51228 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhen-Hua,Hou, Bo,Yang, Liu,et al. Iridoids and bis-iridoids from Patrinia scabiosaefolia[J]. RSC ADVANCES,2017,7(40):24940-24949. |
| APA | Liu, Zhen-Hua.,Hou, Bo.,Yang, Liu.,Ma, Rui-Jing.,Li, Jin-Yu.,...&Zhou, Jun.(2017).Iridoids and bis-iridoids from Patrinia scabiosaefolia.RSC ADVANCES,7(40),24940-24949. |
| MLA | Liu, Zhen-Hua,et al."Iridoids and bis-iridoids from Patrinia scabiosaefolia".RSC ADVANCES 7.40(2017):24940-24949. |
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