Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp TJ23
Hu, Zhengxi1; Sun, Weiguang1; Li, Qin1; Li, Xiao-Nian1,2; Zhu, Hucheng; Huang, Jinfeng1; Liu, Junjun1; Wang, Jianping1; Xue, Yongbo1; Zhang, Yonghui1
2017-03-17
Source PublicationJOURNAL OF ORGANIC CHEMISTRY
Volume82Issue:6Pages:3125-3131
AbstractBioassay-guided isolation of cultures of Aspergillus sp. TJ23 yielded a novel terpene-polyketide hybrid spiromeroterpenoid, spiroaspertrione A (1), bearing a unique spiro[bicydo[3.2.2]nonane-2,1'-cyclohexane] carbocydic skeleton, and a new biointermediate, andiconin B (2). Their structures and absolute configurations were elucidated by spectroscopic analyses, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compound 1 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold from 32 to 1 mu g/mL.
DOI10.1021/acs.joc.7b00056
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000397077500031
Citation statistics
Cited Times:38[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/51007
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
Recommended Citation
GB/T 7714
Hu, Zhengxi,Sun, Weiguang,Li, Qin,et al. Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp TJ23[J]. JOURNAL OF ORGANIC CHEMISTRY,2017,82(6):3125-3131.
APA Hu, Zhengxi.,Sun, Weiguang.,Li, Qin.,Li, Xiao-Nian.,Zhu, Hucheng.,...&Zhang, Yonghui.(2017).Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp TJ23.JOURNAL OF ORGANIC CHEMISTRY,82(6),3125-3131.
MLA Hu, Zhengxi,et al."Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp TJ23".JOURNAL OF ORGANIC CHEMISTRY 82.6(2017):3125-3131.
Files in This Item: Download All
File Name/Size DocType Version Access License
acs.joc.7b00056.pdf(1656KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hu, Zhengxi]'s Articles
[Sun, Weiguang]'s Articles
[Li, Qin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hu, Zhengxi]'s Articles
[Sun, Weiguang]'s Articles
[Li, Qin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hu, Zhengxi]'s Articles
[Sun, Weiguang]'s Articles
[Li, Qin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: acs.joc.7b00056.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.