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题名: Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp TJ23
作者: Hu, Zhengxi1; Sun, Weiguang1; Li, Qin1; Li, Xiao-Nian1, 2; Zhu, Hucheng; Huang, Jinfeng1; Liu, Junjun1; Wang, Jianping1; Xue, Yongbo1; Zhang, Yonghui1
刊名: JOURNAL OF ORGANIC CHEMISTRY
英文摘要: Bioassay-guided isolation of cultures of Aspergillus sp. TJ23 yielded a novel terpene-polyketide hybrid spiromeroterpenoid, spiroaspertrione A (1), bearing a unique spiro[bicydo[3.2.2]nonane-2,1'-cyclohexane] carbocydic skeleton, and a new biointermediate, andiconin B (2). Their structures and absolute configurations were elucidated by spectroscopic analyses, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compound 1 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold from 32 to 1 mu g/mL.
出版日期: 2017-03-17
卷号: 82, 期号:6, 页码:3125-3131
语种: 英语
收录类别: SCI
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/51007
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

Recommended Citation:
Hu, Zhengxi,Sun, Weiguang,Li, Qin,et al. Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp TJ23[J]. JOURNAL OF ORGANIC CHEMISTRY,2017,82(6):3125-3131.
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