Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp TJ23

doi:10.1021/acs.joc.7b00056

	Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp TJ23
	Hu, Zhengxi 1; Sun, Weiguang 1; Li, Qin 1; Li, Xiao-Nian 1,2; Zhu, Hucheng ; Huang, Jinfeng 1; Liu, Junjun 1; Wang, Jianping 1; Xue, Yongbo 1; Zhang, Yonghui 1
	2017-03-17
发表期刊	JOURNAL OF ORGANIC CHEMISTRY
卷号	82 期号:6 页码:3125-3131
摘要	Bioassay-guided isolation of cultures of Aspergillus sp. TJ23 yielded a novel terpene-polyketide hybrid spiromeroterpenoid, spiroaspertrione A (1), bearing a unique spiro[bicydo[3.2.2]nonane-2,1'-cyclohexane] carbocydic skeleton, and a new biointermediate, andiconin B (2). Their structures and absolute configurations were elucidated by spectroscopic analyses, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compound 1 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold from 32 to 1 mu g/mL.
DOI	10.1021/acs.joc.7b00056
收录类别	SCI
语种	英语
WOS记录号	WOS:000397077500031
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/51007
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Hu, Zhengxi,Sun, Weiguang,Li, Qin,et al. Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp TJ23[J]. JOURNAL OF ORGANIC CHEMISTRY,2017,82(6):3125-3131.
APA	Hu, Zhengxi.,Sun, Weiguang.,Li, Qin.,Li, Xiao-Nian.,Zhu, Hucheng.,...&Zhang, Yonghui.(2017).Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp TJ23.JOURNAL OF ORGANIC CHEMISTRY,82(6),3125-3131.
MLA	Hu, Zhengxi,et al."Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp TJ23".JOURNAL OF ORGANIC CHEMISTRY 82.6(2017):3125-3131.

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