Diterpenoid Constituents of the Roots of Salvia digitaloides

doi:10.1021/jf103366g

	Diterpenoid Constituents of the Roots of Salvia digitaloides
	Xu, Gang1 ; Yang, Jing2 ; Wang, Yuan-Yuan 1; Peng, Li-Yan 1; Yang, Xian-Wen 3; Pan, Zheng-Hong 1; Liu, En-De1 ; Li, Yan1 ; Zhao, Qin-Shi1
	2010-12-08
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	0021-8561
卷号	58 期号:23 页码:12157-12161
摘要	Salvia digitaloides, belonging to the economically and medicinally important genus Salvia, is distributed in the northwest of Yunnan Province, People's Republic of China. The roots of this plant were soaked in alcohol by local Tibetans to make a special traditional "red wine", and many local people like to drink this traditional "red wine" to strengthen physical health. To investigate the bioactive diterpenoid constituents of the roots, a detailed phytochemical study was carried out, and 13 diterpenoids including two new norditerpenoids, dihydroneotanshinlactone (1) and 16,17-dinorpisferal A (2), were isolated. Their structures were established on the basis of detailed spectroscopic analysis. In addition, computational methods were applied to validate the stereochemistry of compound 1. For the bioassay to inhibit the growth of five tumor cell lines, neotanshinlactone (3) exhibited selective cytotoxic activity toward the human breast cancer cell line SK-BR-3, while the other four tanshinones (4-7) showed significant toxicity effects against all of the tested five cell lines.
关键词	Salvia Digitaloides Cytotoxic Activity Diterpenoids Stereochemistry
学科领域	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
DOI	10.1021/jf103366g
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000284672800015
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4948
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Chem & Chem Technol, Shanghai 200240, Peoples R China 3.Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Xu, Gang,Yang, Jing,Wang, Yuan-Yuan,et al. Diterpenoid Constituents of the Roots of Salvia digitaloides[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2010,58(23):12157-12161.
APA	Xu, Gang.,Yang, Jing.,Wang, Yuan-Yuan.,Peng, Li-Yan.,Yang, Xian-Wen.,...&Zhao, Qin-Shi.(2010).Diterpenoid Constituents of the Roots of Salvia digitaloides.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,58(23),12157-12161.
MLA	Xu, Gang,et al."Diterpenoid Constituents of the Roots of Salvia digitaloides".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 58.23(2010):12157-12161.

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