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题名: Diterpenoid Constituents of the Roots of Salvia digitaloides
作者: null(许刚)1; Yang, Jing2; Wang, Yuan-Yuan1; Peng, Li-Yan1; Yang, Xian-Wen3; Pan, Zheng-Hong1; Liu, En-De1; null(李艳)1; null(赵勤实)1
刊名: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
关键词: Salvia digitaloides ; cytotoxic activity ; diterpenoids ; stereochemistry
英文摘要: Salvia digitaloides, belonging to the economically and medicinally important genus Salvia, is distributed in the northwest of Yunnan Province, People's Republic of China. The roots of this plant were soaked in alcohol by local Tibetans to make a special traditional "red wine", and many local people like to drink this traditional "red wine" to strengthen physical health. To investigate the bioactive diterpenoid constituents of the roots, a detailed phytochemical study was carried out, and 13 diterpenoids including two new norditerpenoids, dihydroneotanshinlactone (1) and 16,17-dinorpisferal A (2), were isolated. Their structures were established on the basis of detailed spectroscopic analysis. In addition, computational methods were applied to validate the stereochemistry of compound 1. For the bioassay to inhibit the growth of five tumor cell lines, neotanshinlactone (3) exhibited selective cytotoxic activity toward the human breast cancer cell line SK-BR-3, while the other four tanshinones (4-7) showed significant toxicity effects against all of the tested five cell lines.
出版日期: 2010-12-08
卷号: 58, 期号:23, 页码:12157-12161
DOI标识: 10.1021/jf103366g
语种: 英语
收录类别: SCI ; IC
学科分类: Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology
ISSN号: 0021-8561
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4948
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Chem & Chem Technol, Shanghai 200240, Peoples R China
3.Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China

Recommended Citation:
Xu, G; Yang, J; Wang, YY; Peng, LY; Yang, XW; Pan, ZH; Liu, ED; Li, Y; Zhao, QS.Diterpenoid Constituents of the Roots of Salvia digitaloides,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2010,58(23):12157-12161
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