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题名: Melodinines A-G, Monoterpenoid Indole Alkaloids from Melodinus henryi
作者: Feng, Tao1, 2; null(蔡祥海)1; Liu, Ya-Ping1, 2; null(李艳)1; Wang, Yuan-Yuan1; null(罗晓东)1
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: ANTI-HIV ACTIVITY ; VAR. PROPINQUA ; UNIQUE SKELETON ; LANCIFOLIA ; MICRANTHA ; SCHIARTANE ; CHINENSIS
英文摘要: Nineteen monoterpenoid indole alkaloids including seven new ones, melodinines A-G (1-7), were isolated from Melodinus henryi. The structures of the new compounds were elucidated using spectroscopic methods, and the Structure of compound 4 was confirmed by single-crystal X-ray diffraction analysis. The known compounds were identified by comparing their spectroscopic data with those reported in the literature. All of the compounds were evaluated for cytotoxic activity against live human cancer cell lines, and compound 11 exhibited cytotoxicity against HL-60, SMMC-7721, A-549, and SK-BR-3 cells with IC(50) values of 2.0, 16.8, 25.9. and 24.7 mu M, respectively.
出版日期: 2010
卷号: 73, 期号:1, 页码:22-26
DOI标识: 10.1021/np900595v
语种: 英语
收录类别: SCI ; IC
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4888
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Feng, T; Cai, XH; Liu, YP; Li, Y; Wang, YY; Luo, XD.Melodinines A-G, Monoterpenoid Indole Alkaloids from Melodinus henryi,JOURNAL OF NATURAL PRODUCTS,2010,73(1):22-26
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