Potent alpha-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major
Chan, Hsiu-Hui1; Sun, Han-Dong2; Reddy, Mopur Vijaya Bhaskar1; Wu, Tian-Shung1,3
2010-08-01
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume71Issue:11-12Pages:1360-1364
AbstractBioassay-guided fractionation of the CHCl(3) soluble portion of the roots of Panax japonicus C. A. Meyer var. major afforded an active fraction with inhibitory activity against baker's yeast alpha-glucosidase with an IC(50) value 1.02 mg/mL. Furthermore, the active fraction isolated contained three previously unreported polyacetylenes, designated panaxjapynes A-C, together with 11 other compounds, including four polyacetylenes, five phenolic compounds, a sesquiterpenoid, and a sterol glucoside. The structures of the compounds were elucidated by spectroscopic and chemical methods. Compared with the control acarbose (IC(50) 677.97 mu M), six compounds were shown to be more potent alpha-glucosidase inhibitors with IC(50) values in the range 22.21-217.68 mu M. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.
KeywordAraliaceae PA.A. JA.oniC.s C. A. Meyer vA.. mA.or Zu-tziseng Polyacetylene Acarbose Alpha-glucosidase Inhibitors
Subject AreaBiochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytochem.2010.04.013
Indexed BySCI ; IC
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000280321000018
Citation statistics
Cited Times:36[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4866
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.China Med Univ, Dept Pharm, Taichung 40402, Taiwan
Recommended Citation
GB/T 7714
Chan, Hsiu-Hui,Sun, Han-Dong,Reddy, Mopur Vijaya Bhaskar,et al. Potent alpha-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major[J]. PHYTOCHEMISTRY,2010,71(11-12):1360-1364.
APA Chan, Hsiu-Hui,Sun, Han-Dong,Reddy, Mopur Vijaya Bhaskar,&Wu, Tian-Shung.(2010).Potent alpha-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major.PHYTOCHEMISTRY,71(11-12),1360-1364.
MLA Chan, Hsiu-Hui,et al."Potent alpha-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major".PHYTOCHEMISTRY 71.11-12(2010):1360-1364.
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