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题名: Potent alpha-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major
作者: Chan, Hsiu-Hui1; null(孙汉董)2; Reddy, Mopur Vijaya Bhaskar1; Wu, Tian-Shung1, 3
刊名: PHYTOCHEMISTRY
关键词: Araliaceae ; Panax japonicus C. A. Meyer var. major ; Zu-Tziseng ; Polyacetylene ; Acarbose ; alpha-Glucosidase inhibitors
英文摘要: Bioassay-guided fractionation of the CHCl(3) soluble portion of the roots of Panax japonicus C. A. Meyer var. major afforded an active fraction with inhibitory activity against baker's yeast alpha-glucosidase with an IC(50) value 1.02 mg/mL. Furthermore, the active fraction isolated contained three previously unreported polyacetylenes, designated panaxjapynes A-C, together with 11 other compounds, including four polyacetylenes, five phenolic compounds, a sesquiterpenoid, and a sterol glucoside. The structures of the compounds were elucidated by spectroscopic and chemical methods. Compared with the control acarbose (IC(50) 677.97 mu M), six compounds were shown to be more potent alpha-glucosidase inhibitors with IC(50) values in the range 22.21-217.68 mu M. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.
出版日期: 2010-08-01
卷号: 71, 期号:11-12, 页码:1360-1364
DOI标识: 10.1016/j.phytochem.2010.04.013
语种: 英语
收录类别: SCI ; IC
学科分类: Biochemistry & Molecular Biology; Plant Sciences
ISSN号: 0031-9422
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4866
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.China Med Univ, Dept Pharm, Taichung 40402, Taiwan

Recommended Citation:
Chan, HH; Sun, HD; Reddy, MVB; Wu, TS.Potent alpha-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major,PHYTOCHEMISTRY,2010,71(11-12):1360-1364
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