Anti-Coxsackie Virus B3 Norsesquiterpenoids from the Roots of Phyllanthus emblica

doi:10.1021/np800792d

	Anti-Coxsackie Virus B3 Norsesquiterpenoids from the Roots of Phyllanthus emblica
	Liu, Qing 1,2; Wang, Ya-Feng 3; Chen, Rong-Jie 1; Zhang, Mei-Ying 3; Wang, Yi-Fei 3; Yang, Chong-Ren 1; Zhang, Ying-Jun1
	2009-05-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	72 期号:5 页码:969-972
摘要	Three new norsesquiterpenoid glycosides, 4'-hydroxyphyllaemblicin B (1) and phyllaemblicins E (2) and F (3), were isolated from the roots of Phyllanthus emblica, together with three known compounds, phyllaemblic acid (4), phyllaemblicin B (5), and phyllaemblicin C (6). Of these, 3 is a new norsesquiterpenoid dimer. The structures of 1-3 were established by spectroscopic data information and by acidic hydrolysis. The isolated compounds, together with two other known analogues, phyllaemblic acid methyl ester (7) and phyllaemblicin A (8), were evaluated for their antiviral activity toward coxsackie virus B3 (CVB3) by an in vitro cytopathic effect inhibitory assay. Compounds 5-7 exhibited strong anti-CVB3 activity.
关键词	Hydrogen-peroxide Constituents Inhibitors Leaves Neolignan
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1021/np800792d
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000266389900034
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4802
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Guangzhou Jinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Liu, Qing,Wang, Ya-Feng,Chen, Rong-Jie,et al. Anti-Coxsackie Virus B3 Norsesquiterpenoids from the Roots of Phyllanthus emblica[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(5):969-972.
APA	Liu, Qing.,Wang, Ya-Feng.,Chen, Rong-Jie.,Zhang, Mei-Ying.,Wang, Yi-Fei.,...&Zhang, Ying-Jun.(2009).Anti-Coxsackie Virus B3 Norsesquiterpenoids from the Roots of Phyllanthus emblica.JOURNAL OF NATURAL PRODUCTS,72(5),969-972.
MLA	Liu, Qing,et al."Anti-Coxsackie Virus B3 Norsesquiterpenoids from the Roots of Phyllanthus emblica".JOURNAL OF NATURAL PRODUCTS 72.5(2009):969-972.

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