Anti-Coxsackie Virus B3 Norsesquiterpenoids from the Roots of Phyllanthus emblica
Liu, Qing1,2; Wang, Ya-Feng3; Chen, Rong-Jie1; Zhang, Mei-Ying3; Wang, Yi-Fei3; Yang, Chong-Ren1; Zhang, Ying-Jun1
2009-05-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号72期号:5页码:969-972
摘要Three new norsesquiterpenoid glycosides, 4'-hydroxyphyllaemblicin B (1) and phyllaemblicins E (2) and F (3), were isolated from the roots of Phyllanthus emblica, together with three known compounds, phyllaemblic acid (4), phyllaemblicin B (5), and phyllaemblicin C (6). Of these, 3 is a new norsesquiterpenoid dimer. The structures of 1-3 were established by spectroscopic data information and by acidic hydrolysis. The isolated compounds, together with two other known analogues, phyllaemblic acid methyl ester (7) and phyllaemblicin A (8), were evaluated for their antiviral activity toward coxsackie virus B3 (CVB3) by an in vitro cytopathic effect inhibitory assay. Compounds 5-7 exhibited strong anti-CVB3 activity.
关键词Hydrogen-peroxide Constituents Inhibitors Leaves Neolignan
资助信息NSFC [U0632010]; Chinese Academy of Sciences [O807B11211, O807E21211]
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np800792d
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000266389900034
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4802
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Guangzhou Jinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
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Liu, Qing,Wang, Ya-Feng,Chen, Rong-Jie,et al. Anti-Coxsackie Virus B3 Norsesquiterpenoids from the Roots of Phyllanthus emblica[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(5):969-972.
APA Liu, Qing.,Wang, Ya-Feng.,Chen, Rong-Jie.,Zhang, Mei-Ying.,Wang, Yi-Fei.,...&Zhang, Ying-Jun.(2009).Anti-Coxsackie Virus B3 Norsesquiterpenoids from the Roots of Phyllanthus emblica.JOURNAL OF NATURAL PRODUCTS,72(5),969-972.
MLA Liu, Qing,et al."Anti-Coxsackie Virus B3 Norsesquiterpenoids from the Roots of Phyllanthus emblica".JOURNAL OF NATURAL PRODUCTS 72.5(2009):969-972.
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