Anti-Coxsackie Virus B3 Norsesquiterpenoids from the Roots of Phyllanthus emblica
Liu, Qing1,2; Wang, Ya-Feng3; Chen, Rong-Jie1; Zhang, Mei-Ying3; Wang, Yi-Fei3; Yang, Chong-Ren1; Zhang, Ying-Jun1
2009-05-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume72Issue:5Pages:969-972
AbstractThree new norsesquiterpenoid glycosides, 4'-hydroxyphyllaemblicin B (1) and phyllaemblicins E (2) and F (3), were isolated from the roots of Phyllanthus emblica, together with three known compounds, phyllaemblic acid (4), phyllaemblicin B (5), and phyllaemblicin C (6). Of these, 3 is a new norsesquiterpenoid dimer. The structures of 1-3 were established by spectroscopic data information and by acidic hydrolysis. The isolated compounds, together with two other known analogues, phyllaemblic acid methyl ester (7) and phyllaemblicin A (8), were evaluated for their antiviral activity toward coxsackie virus B3 (CVB3) by an in vitro cytopathic effect inhibitory assay. Compounds 5-7 exhibited strong anti-CVB3 activity.
KeywordHydrogen-peroxide Constituents Inhibitors Leaves Neolignan
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np800792d
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000266389900034
Citation statistics
Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4802
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Guangzhou Jinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Liu, Qing,Wang, Ya-Feng,Chen, Rong-Jie,et al. Anti-Coxsackie Virus B3 Norsesquiterpenoids from the Roots of Phyllanthus emblica[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(5):969-972.
APA Liu, Qing.,Wang, Ya-Feng.,Chen, Rong-Jie.,Zhang, Mei-Ying.,Wang, Yi-Fei.,...&Zhang, Ying-Jun.(2009).Anti-Coxsackie Virus B3 Norsesquiterpenoids from the Roots of Phyllanthus emblica.JOURNAL OF NATURAL PRODUCTS,72(5),969-972.
MLA Liu, Qing,et al."Anti-Coxsackie Virus B3 Norsesquiterpenoids from the Roots of Phyllanthus emblica".JOURNAL OF NATURAL PRODUCTS 72.5(2009):969-972.
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