Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis

doi:10.1021/np900123z

	Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis
	Li, Xiao-Nian 1,6; Pu, Jian-Xin1 ; Du, Xue 1; Yang, Liu-Meng 2,3; An, Hui-Mei 4,5; Lei, Chun 1; He, Fei 1; Luo, Xiao 1; Zheng, Yong-Tang 2,3; Lu, Yang 4,5; Xiao, Wei-Lie 1; Sun, Han-Dong1
	2009-06-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	72 期号:6 页码:1133-1141
摘要	Fourteen new lignans, tiegusanins A-N (1-14), together with 13 known compounds were isolated from the aerial parts of Schisandra propinqua var. sinensis. The structures and absolute configurations of 1-13 were established using a combination of spectroscopic techniques. Compound 14 was obtained as a racemate. When evaluated for inhibitory activity against HIV-1, tiegusanin G (7) showed anti-HIV-1 activity with an EC(50) value of 7.9 mu M and a therapeutic index (TI) of more than 25.
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1021/np900123z
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000267432600028
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4800
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mechanisms, Kunming 650223, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China 4.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 5.Peking Union Med Coll, Beijing 100050, Peoples R China 6.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Li, Xiao-Nian,Pu, Jian-Xin,Du, Xue,et al. Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(6):1133-1141.
APA	Li, Xiao-Nian.,Pu, Jian-Xin.,Du, Xue.,Yang, Liu-Meng.,An, Hui-Mei.,...&Sun, Han-Dong.(2009).Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis.JOURNAL OF NATURAL PRODUCTS,72(6),1133-1141.
MLA	Li, Xiao-Nian,et al."Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis".JOURNAL OF NATURAL PRODUCTS 72.6(2009):1133-1141.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
201202230034.pdf（337KB）			开放获取	--	浏览下载