Monoterpenoid Indole Alkaloids from Alstonia yunnanensis
Feng, Tao1,2; Li, Yan1; Cai, Xiang-Hai1; Gong, Xun1; Liu, Ya-Ping1,2; Zhang, Rong-Ting1,2; Zhang, Xiang-Yun1,2; Tan, Qin-Gang1,2; Luo, Xiao-Dong1
2009-10-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume72Issue:10Pages:1836-1841
AbstractEight new monoterpenoid indole alkaloids, alstoyunines A-H (1-8), along with 17 known analogues, were isolated from Alstonia yunnanensis. The structures of. the new alkaloids were established by means of extensive spectroscopic methods. Alstoyunines C (3), E (5), and F (6) showed selective inhibition of Cox-2 (>75%). Alstoyunine F (6) showed weak cytotoxicity against the human myeloid leukemia HL-60 (IC(50) = 3.89 mu M) and hepatocellular carcinoma SMMC-7721 (IC(50) = 21.73 mu M) cell lines.
KeywordCultures Antifungal Metabolite Couplings
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np900374s
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000271950400017
Citation statistics
Cited Times:45[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4794
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Feng, Tao,Li, Yan,Cai, Xiang-Hai,et al. Monoterpenoid Indole Alkaloids from Alstonia yunnanensis[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(10):1836-1841.
APA Feng, Tao.,Li, Yan.,Cai, Xiang-Hai.,Gong, Xun.,Liu, Ya-Ping.,...&Luo, Xiao-Dong.(2009).Monoterpenoid Indole Alkaloids from Alstonia yunnanensis.JOURNAL OF NATURAL PRODUCTS,72(10),1836-1841.
MLA Feng, Tao,et al."Monoterpenoid Indole Alkaloids from Alstonia yunnanensis".JOURNAL OF NATURAL PRODUCTS 72.10(2009):1836-1841.
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