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题名: Monoterpenoid Indole Alkaloids from Alstonia yunnanensis
作者: Feng, Tao1, 2; null(李艳)1; null(蔡祥海)1; null(龚洵)1; Liu, Ya-Ping1, 2; Zhang, Rong-Ting1, 2; Zhang, Xiang-Yun1, 2; Tan, Qin-Gang1, 2; null(罗晓东)1
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: CULTURES ; ANTIFUNGAL ; METABOLITE ; COUPLINGS
英文摘要: Eight new monoterpenoid indole alkaloids, alstoyunines A-H (1-8), along with 17 known analogues, were isolated from Alstonia yunnanensis. The structures of. the new alkaloids were established by means of extensive spectroscopic methods. Alstoyunines C (3), E (5), and F (6) showed selective inhibition of Cox-2 (>75%). Alstoyunine F (6) showed weak cytotoxicity against the human myeloid leukemia HL-60 (IC(50) = 3.89 mu M) and hepatocellular carcinoma SMMC-7721 (IC(50) = 21.73 mu M) cell lines.
出版日期: 2009-10-01
卷号: 72, 期号:10, 页码:1836-1841
DOI标识: 10.1021/np900374s
语种: 英语
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4794
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Feng, T; Li, Y; Cai, XH; Gong, X; Liu, YP; Zhang, RT; Zhang, XY; Tan, QG; Luo, XD.Monoterpenoid Indole Alkaloids from Alstonia yunnanensis,JOURNAL OF NATURAL PRODUCTS,2009,72(10):1836-1841
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