| Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells | |
| Zeng, Guang-Zhi1; Tan, Ning-Hua1; Ji, Chang-Jiu1,2; Fan, Jun-Ting1,2; Huang, Huo-Qiang1,2; Han, Hong-Jin1; Zhou, Guang-Biao3 | |
| 2009-06-01 | |
| 发表期刊 | PHYTOTHERAPY RESEARCH
 |
| ISSN | 0951-418X |
| 卷号 | 23期号:6页码:885-891 |
| 摘要 | Inula helianthus-aquatica C. Y. Wu is a traditional medicinal plant used to treat some cancers in folk herbal medicine of Yunnan, China. Bigelovin, a sesquiterpene lactone isolated from this herb, potently inhibits the growth of a panel of eight cancer cell lines, especially in human monoblastic leukemia U937 cells with an IC(50) value of 0.47 mu M. Characteristic morphological features of apoptosis were observed in U937 cells treated with bigelovin. Annexin V and nuclear DNA content distribution assays showed that the percentage of Annexin V positive cells increased to 8.86% (24 h) with 1 mu M bigelovin treatment, and cells treated with bigelovin at this concentration apparently arrested at G(0)/G(1), phase compared with the control. These data suggested that cytotoxic effect of bigelovin on U937 cells involves induction of apoptosis, and the cell cycle is arrested at G(0)/G(1) phase. Copyright (C) 2008 John Wiley & Sons, Ltd. |
| 关键词 | Bigelovin Inula Helianthus-aquatica Cancer Cells Apoptosis U937 |
| 学科领域 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1002/ptr.2671 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000267088400024 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/4782 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510663, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Guang-Zhi,Tan, Ning-Hua,Ji, Chang-Jiu,et al. Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells[J]. PHYTOTHERAPY RESEARCH,2009,23(6):885-891. |
| APA | Zeng, Guang-Zhi.,Tan, Ning-Hua.,Ji, Chang-Jiu.,Fan, Jun-Ting.,Huang, Huo-Qiang.,...&Zhou, Guang-Biao.(2009).Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells.PHYTOTHERAPY RESEARCH,23(6),885-891. |
| MLA | Zeng, Guang-Zhi,et al."Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells".PHYTOTHERAPY RESEARCH 23.6(2009):885-891. |
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