Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells
Zeng, Guang-Zhi1; Tan, Ning-Hua1; Ji, Chang-Jiu1,2; Fan, Jun-Ting1,2; Huang, Huo-Qiang1,2; Han, Hong-Jin1; Zhou, Guang-Biao3
2009-06-01
Source PublicationPHYTOTHERAPY RESEARCH
ISSN0951-418X
Volume23Issue:6Pages:885-891
AbstractInula helianthus-aquatica C. Y. Wu is a traditional medicinal plant used to treat some cancers in folk herbal medicine of Yunnan, China. Bigelovin, a sesquiterpene lactone isolated from this herb, potently inhibits the growth of a panel of eight cancer cell lines, especially in human monoblastic leukemia U937 cells with an IC(50) value of 0.47 mu M. Characteristic morphological features of apoptosis were observed in U937 cells treated with bigelovin. Annexin V and nuclear DNA content distribution assays showed that the percentage of Annexin V positive cells increased to 8.86% (24 h) with 1 mu M bigelovin treatment, and cells treated with bigelovin at this concentration apparently arrested at G(0)/G(1), phase compared with the control. These data suggested that cytotoxic effect of bigelovin on U937 cells involves induction of apoptosis, and the cell cycle is arrested at G(0)/G(1) phase. Copyright (C) 2008 John Wiley & Sons, Ltd.
KeywordBigelovin Inula Helianthus-aquatica Cancer Cells Apoptosis U937
Subject AreaChemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1002/ptr.2671
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000267088400024
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4782
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510663, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Zeng, Guang-Zhi,Tan, Ning-Hua,Ji, Chang-Jiu,et al. Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells[J]. PHYTOTHERAPY RESEARCH,2009,23(6):885-891.
APA Zeng, Guang-Zhi.,Tan, Ning-Hua.,Ji, Chang-Jiu.,Fan, Jun-Ting.,Huang, Huo-Qiang.,...&Zhou, Guang-Biao.(2009).Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells.PHYTOTHERAPY RESEARCH,23(6),885-891.
MLA Zeng, Guang-Zhi,et al."Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells".PHYTOTHERAPY RESEARCH 23.6(2009):885-891.
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