Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells
Zeng, Guang-Zhi1; Tan, Ning-Hua1; Ji, Chang-Jiu1,2; Fan, Jun-Ting1,2; Huang, Huo-Qiang1,2; Han, Hong-Jin1; Zhou, Guang-Biao3
2009-06-01
发表期刊PHYTOTHERAPY RESEARCH
ISSN0951-418X
卷号23期号:6页码:885-891
摘要Inula helianthus-aquatica C. Y. Wu is a traditional medicinal plant used to treat some cancers in folk herbal medicine of Yunnan, China. Bigelovin, a sesquiterpene lactone isolated from this herb, potently inhibits the growth of a panel of eight cancer cell lines, especially in human monoblastic leukemia U937 cells with an IC(50) value of 0.47 mu M. Characteristic morphological features of apoptosis were observed in U937 cells treated with bigelovin. Annexin V and nuclear DNA content distribution assays showed that the percentage of Annexin V positive cells increased to 8.86% (24 h) with 1 mu M bigelovin treatment, and cells treated with bigelovin at this concentration apparently arrested at G(0)/G(1), phase compared with the control. These data suggested that cytotoxic effect of bigelovin on U937 cells involves induction of apoptosis, and the cell cycle is arrested at G(0)/G(1) phase. Copyright (C) 2008 John Wiley & Sons, Ltd.
关键词Bigelovin Inula Helianthus-aquatica Cancer Cells Apoptosis U937
资助信息National Natural Science Foundation of China [30725048]; Foundation of Chinese Academy of Sciences [KSCX1-09-03-1, KSCX-SW-11]
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1002/ptr.2671
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000267088400024
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4782
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510663, Guangdong, Peoples R China
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Zeng, Guang-Zhi,Tan, Ning-Hua,Ji, Chang-Jiu,et al. Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells[J]. PHYTOTHERAPY RESEARCH,2009,23(6):885-891.
APA Zeng, Guang-Zhi.,Tan, Ning-Hua.,Ji, Chang-Jiu.,Fan, Jun-Ting.,Huang, Huo-Qiang.,...&Zhou, Guang-Biao.(2009).Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells.PHYTOTHERAPY RESEARCH,23(6),885-891.
MLA Zeng, Guang-Zhi,et al."Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells".PHYTOTHERAPY RESEARCH 23.6(2009):885-891.
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