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题名: Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells
作者: Zeng, Guang-Zhi1; Tan, Ning-Hua1; Ji, Chang-Jiu1, 2; Fan, Jun-Ting1, 2; Huang, Huo-Qiang1, 2; Han, Hong-Jin1; Zhou, Guang-Biao3
刊名: PHYTOTHERAPY RESEARCH
关键词: Bigelovin ; Inula helianthus-aquatica ; cancer cells ; apoptosis ; U937
英文摘要: Inula helianthus-aquatica C. Y. Wu is a traditional medicinal plant used to treat some cancers in folk herbal medicine of Yunnan, China. Bigelovin, a sesquiterpene lactone isolated from this herb, potently inhibits the growth of a panel of eight cancer cell lines, especially in human monoblastic leukemia U937 cells with an IC(50) value of 0.47 mu M. Characteristic morphological features of apoptosis were observed in U937 cells treated with bigelovin. Annexin V and nuclear DNA content distribution assays showed that the percentage of Annexin V positive cells increased to 8.86% (24 h) with 1 mu M bigelovin treatment, and cells treated with bigelovin at this concentration apparently arrested at G(0)/G(1), phase compared with the control. These data suggested that cytotoxic effect of bigelovin on U937 cells involves induction of apoptosis, and the cell cycle is arrested at G(0)/G(1) phase. Copyright (C) 2008 John Wiley & Sons, Ltd.
出版日期: 2009-06-01
卷号: 23, 期号:6, 页码:885-891
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0951-418X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4782
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510663, Guangdong, Peoples R China

Recommended Citation:
Zeng, GZ; Tan, NH; Ji, CJ; Fan, JT; Huang, HQ; Han, HJ; Zhou, GB.Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells,PHYTOTHERAPY RESEARCH,2009,23(6):885-891
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