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题名: Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro
作者: Ye, M; Liu, JK; Lu, ZX; Zhao, Y; Liu, SF; Li, LL; Tan, M; Weng, XX; null(李唯奇); Cao, Y
刊名: FEBS LETTERS
关键词: antitumor ; mushroom grifolin ; apoptosis
英文摘要: Grifolin is a natural biologically active substance isolated from the fresh fruiting bodies of the mushroom Albatrellus confluens. Here, for the first time, we describe a novel activity of grifolin, namely its ability to inhibit the growth of tumor cells by the induction of apoptosis. Grifolin strongly inhibited the growth of tumor cell lines: CNE1, HeLa, MCF7, SW480, K562, Raji and B95-8. Analysis of acridine orange (AO)/ethidium bromide (EB) staining and flow cytometry showed that grifolin possessed apoptosis induction activity to CNE1, HeLa, MCF7 and SW480. Furthermore, the cytochrome c release from mitochondria was detected by confocal microscopy in CNEI cells after a 12 h treatment with grifolin. The increase of caspase-8, 9, 3 activities revealed that caspase was a key mediator of the apoptotic pathway induced by grifolin, and the underexpression of Bcl-2 and up-regulation of Bax resulted in the increase of Bax: Bel-2 ratio, suggesting that Bcl-2 family involved in the control of apoptosis. Owing to the combination of the significant antitumor activity by inducing apoptosis and natural abundance of the compound, grifolin holds the promise of being an interesting antitumor agent that deserves further laboratory and in vivo exploration. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
出版日期: 2005-06-20
卷号: 579, 期号:16, 页码:3437-3443
DOI标识: 10.1016/j.febslet.2005.05.013
语种: 英语
收录类别: SCI
学科分类: Biochemistry & Molecular Biology; Biophysics; Cell Biology
ISSN号: 0014-5793
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4686
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, Dept Phytochem, Kunming 650204, Yunnan, Peoples R China
2.Cent S Univ, Xiangya Sch Med, Inst Canc Res, Changsha 410078, Hunan, Peoples R China

Recommended Citation:
Ye, M; Liu, JK; Lu, ZX; Zhao, Y; Liu, SF; Li, LL; Tan, M; Weng, XX; Li, W; Cao, Y.Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro,FEBS LETTERS,2005,579(16):3437-3443
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