Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro
Ye, M; Liu, JK; Lu, ZX; Zhao, Y; Liu, SF; Li, LL; Tan, M; Weng, XX; Li, W; Cao, Y
2005-06-20
发表期刊FEBS LETTERS
ISSN0014-5793
卷号579期号:16页码:3437-3443
摘要Grifolin is a natural biologically active substance isolated from the fresh fruiting bodies of the mushroom Albatrellus confluens. Here, for the first time, we describe a novel activity of grifolin, namely its ability to inhibit the growth of tumor cells by the induction of apoptosis. Grifolin strongly inhibited the growth of tumor cell lines: CNE1, HeLa, MCF7, SW480, K562, Raji and B95-8. Analysis of acridine orange (AO)/ethidium bromide (EB) staining and flow cytometry showed that grifolin possessed apoptosis induction activity to CNE1, HeLa, MCF7 and SW480. Furthermore, the cytochrome c release from mitochondria was detected by confocal microscopy in CNEI cells after a 12 h treatment with grifolin. The increase of caspase-8, 9, 3 activities revealed that caspase was a key mediator of the apoptotic pathway induced by grifolin, and the underexpression of Bcl-2 and up-regulation of Bax resulted in the increase of Bax: Bel-2 ratio, suggesting that Bcl-2 family involved in the control of apoptosis. Owing to the combination of the significant antitumor activity by inducing apoptosis and natural abundance of the compound, grifolin holds the promise of being an interesting antitumor agent that deserves further laboratory and in vivo exploration. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
关键词Antitumor Mushroom Grifolin Apoptosis
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4686
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Dept Phytochem, Kunming 650204, Yunnan, Peoples R China
2.Cent S Univ, Xiangya Sch Med, Inst Canc Res, Changsha 410078, Hunan, Peoples R China
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Ye, M,Liu, JK,Lu, ZX,et al. Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro[J]. FEBS LETTERS,2005,579(16):3437-3443.
APA Ye, M.,Liu, JK.,Lu, ZX.,Zhao, Y.,Liu, SF.,...&Cao, Y.(2005).Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro.FEBS LETTERS,579(16),3437-3443.
MLA Ye, M,et al."Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro".FEBS LETTERS 579.16(2005):3437-3443.
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