Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro

doi:10.1016/j.febslet.2005.05.013

	Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro
	Ye, M ; Liu, JK ; Lu, ZX ; Zhao, Y ; Liu, SF ; Li, LL ; Tan, M ; Weng, XX ; Li, W; Cao, Y
通讯作者	Liu, JK, Chinese Acad Sci, Kunming Inst Bot, Dept Phytochem, Kunming 650204, Yunnan, Peoples R China
	2005-06-20
发表期刊	FEBS LETTERS
ISSN	0014-5793
卷号	579 期号:16 页码:3437-3443
摘要	Grifolin is a natural biologically active substance isolated from the fresh fruiting bodies of the mushroom Albatrellus confluens. Here, for the first time, we describe a novel activity of grifolin, namely its ability to inhibit the growth of tumor cells by the induction of apoptosis. Grifolin strongly inhibited the growth of tumor cell lines: CNE1, HeLa, MCF7, SW480, K562, Raji and B95-8. Analysis of acridine orange (AO)/ethidium bromide (EB) staining and flow cytometry showed that grifolin possessed apoptosis induction activity to CNE1, HeLa, MCF7 and SW480. Furthermore, the cytochrome c release from mitochondria was detected by confocal microscopy in CNEI cells after a 12 h treatment with grifolin. The increase of caspase-8, 9, 3 activities revealed that caspase was a key mediator of the apoptotic pathway induced by grifolin, and the underexpression of Bcl-2 and up-regulation of Bax resulted in the increase of Bax: Bel-2 ratio, suggesting that Bcl-2 family involved in the control of apoptosis. Owing to the combination of the significant antitumor activity by inducing apoptosis and natural abundance of the compound, grifolin holds the promise of being an interesting antitumor agent that deserves further laboratory and in vivo exploration. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
关键词	Antitumor Mushroom Grifolin Apoptosis
学科领域	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
DOI	10.1016/j.febslet.2005.05.013
收录类别	SCI
语种	英语
WOS记录号	WOS:000230045400014
引用统计	被引频次：78[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4686
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Dept Phytochem, Kunming 650204, Yunnan, Peoples R China 2.Cent S Univ, Xiangya Sch Med, Inst Canc Res, Changsha 410078, Hunan, Peoples R China
推荐引用方式 GB/T 7714	Ye, M,Liu, JK,Lu, ZX,et al. Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro[J]. FEBS LETTERS,2005,579(16):3437-3443.
APA	Ye, M.,Liu, JK.,Lu, ZX.,Zhao, Y.,Liu, SF.,...&Cao, Y.(2005).Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro.FEBS LETTERS,579(16),3437-3443.
MLA	Ye, M,et al."Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro".FEBS LETTERS 579.16(2005):3437-3443.

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