| Novel taxoids from the Chinese yew Taxus yunnanensis | |
Li, SH ; Zhang, HJ; Niu, XM; Yao, P; Sun, HD; Fong, HHS
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| Corresponding Author | Zhang, HJ, Univ Illinois, Program Collaborat Res Pharmaceut Sci, Dept Med Chem & Pharmacognosy, Coll Pharm, 833 S Wood St, Chicago, IL 60612 USA |
| 2003 | |
| Source Publication | TETRAHEDRON
 |
| ISSN | 0040-4020 |
| Volume | 59Issue:1Pages:37-45 |
| Abstract | Six new taxoids, taxuyunnanines W (1), X (2), Y (3), Z (5), 10-deacetyl-10-(beta-glucopyranosyl)-yunnanxane (8), and 7-(beta-xylosyl)-N-methyl-taxol C (10), as well as taxuchin B (4) and yunnanxane (7), have been isolated from the bark of Taxus yunnanensis. Compounds 1 and 2 were characterized as 11 (15-->1)-abeo taxoids containing an orthoester group, which have not been reported from any Taxus plants to date; isolates 3 and 5 are the examples of taxanes having a tetrahydronfuran ring, being reported only for the second time; and 8 is the first natural 6/8/6 skeletal type taxane glucosidic form. This is also the first report of a co-occurrence of xylosidation and N-methylation in a taxane (10). Compound 4 is the only known chlorine-containing taxane found in nature thus far, and is being reported from this plant for the first time. The structures were determined by spectroscopic and chemical means including 1D and 2D NMR spectra. (C) 2002 Elsevier Science Ltd. All rights reserved. |
| Keyword | Taxus Yunnanensis Taxaceae Barks Abeotaxoids Taxane Glycosides Orthoester C-2(20) Epoxide Taxuyunnanines W-z 7-(Beta-xylosyl)-n-methyl-taxol c 10-deacetyl-10-(Beta-glucopyranosyl)-yunnanxane |
| Subject Area | Chemistry, Organic |
| Indexed By | SCI ; IC |
| Language | 英语 |
| WOS ID | WOS:000180271500002 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/4606 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Univ Illinois, Program Collaborat Res Pharmaceut Sci, Dept Med Chem & Pharmacognosy, Coll Pharm, Chicago, IL 60612 USA 2.Chinese Acad Sci, Lab Phytochem, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Li, SH,Zhang, HJ,Niu, XM,et al. Novel taxoids from the Chinese yew Taxus yunnanensis[J]. TETRAHEDRON,2003,59(1):37-45. |
| APA | Li, SH,Zhang, HJ,Niu, XM,Yao, P,Sun, HD,&Fong, HHS.(2003).Novel taxoids from the Chinese yew Taxus yunnanensis.TETRAHEDRON,59(1),37-45. |
| MLA | Li, SH,et al."Novel taxoids from the Chinese yew Taxus yunnanensis".TETRAHEDRON 59.1(2003):37-45. |
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