Novel taxoids from the Chinese yew Taxus yunnanensis
Li, SH; Zhang, HJ; Niu, XM; Yao, P; Sun, HD; Fong, HHS
Corresponding AuthorZhang, HJ, Univ Illinois, Program Collaborat Res Pharmaceut Sci, Dept Med Chem & Pharmacognosy, Coll Pharm, 833 S Wood St, Chicago, IL 60612 USA
2003
Source PublicationTETRAHEDRON
ISSN0040-4020
Volume59Issue:1Pages:37-45
AbstractSix new taxoids, taxuyunnanines W (1), X (2), Y (3), Z (5), 10-deacetyl-10-(beta-glucopyranosyl)-yunnanxane (8), and 7-(beta-xylosyl)-N-methyl-taxol C (10), as well as taxuchin B (4) and yunnanxane (7), have been isolated from the bark of Taxus yunnanensis. Compounds 1 and 2 were characterized as 11 (15-->1)-abeo taxoids containing an orthoester group, which have not been reported from any Taxus plants to date; isolates 3 and 5 are the examples of taxanes having a tetrahydronfuran ring, being reported only for the second time; and 8 is the first natural 6/8/6 skeletal type taxane glucosidic form. This is also the first report of a co-occurrence of xylosidation and N-methylation in a taxane (10). Compound 4 is the only known chlorine-containing taxane found in nature thus far, and is being reported from this plant for the first time. The structures were determined by spectroscopic and chemical means including 1D and 2D NMR spectra. (C) 2002 Elsevier Science Ltd. All rights reserved.
KeywordTaxus Yunnanensis Taxaceae Barks Abeotaxoids Taxane Glycosides Orthoester C-2(20) Epoxide Taxuyunnanines W-z 7-(Beta-xylosyl)-n-methyl-taxol c 10-deacetyl-10-(Beta-glucopyranosyl)-yunnanxane
Subject AreaChemistry, Organic
Indexed BySCI ; IC
Language英语
WOS IDWOS:000180271500002
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4606
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Univ Illinois, Program Collaborat Res Pharmaceut Sci, Dept Med Chem & Pharmacognosy, Coll Pharm, Chicago, IL 60612 USA
2.Chinese Acad Sci, Lab Phytochem, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Li, SH,Zhang, HJ,Niu, XM,et al. Novel taxoids from the Chinese yew Taxus yunnanensis[J]. TETRAHEDRON,2003,59(1):37-45.
APA Li, SH,Zhang, HJ,Niu, XM,Yao, P,Sun, HD,&Fong, HHS.(2003).Novel taxoids from the Chinese yew Taxus yunnanensis.TETRAHEDRON,59(1),37-45.
MLA Li, SH,et al."Novel taxoids from the Chinese yew Taxus yunnanensis".TETRAHEDRON 59.1(2003):37-45.
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