Novel taxoids from the Chinese yew Taxus yunnanensis

	Novel taxoids from the Chinese yew Taxus yunnanensis
	Li, SH; Zhang, HJ ; Niu, XM ; Yao, P ; Sun, HD; Fong, HHS
通讯作者	Zhang, HJ, Univ Illinois, Program Collaborat Res Pharmaceut Sci, Dept Med Chem & Pharmacognosy, Coll Pharm, 833 S Wood St, Chicago, IL 60612 USA
	2003
发表期刊	TETRAHEDRON
ISSN	0040-4020
卷号	59 期号:1 页码:37-45
摘要	Six new taxoids, taxuyunnanines W (1), X (2), Y (3), Z (5), 10-deacetyl-10-(beta-glucopyranosyl)-yunnanxane (8), and 7-(beta-xylosyl)-N-methyl-taxol C (10), as well as taxuchin B (4) and yunnanxane (7), have been isolated from the bark of Taxus yunnanensis. Compounds 1 and 2 were characterized as 11 (15-->1)-abeo taxoids containing an orthoester group, which have not been reported from any Taxus plants to date; isolates 3 and 5 are the examples of taxanes having a tetrahydronfuran ring, being reported only for the second time; and 8 is the first natural 6/8/6 skeletal type taxane glucosidic form. This is also the first report of a co-occurrence of xylosidation and N-methylation in a taxane (10). Compound 4 is the only known chlorine-containing taxane found in nature thus far, and is being reported from this plant for the first time. The structures were determined by spectroscopic and chemical means including 1D and 2D NMR spectra. (C) 2002 Elsevier Science Ltd. All rights reserved.
关键词	Taxus Yunnanensis Taxaceae Barks Abeotaxoids Taxane Glycosides Orthoester C-2(20) Epoxide Taxuyunnanines W-z 7-(Beta-xylosyl)-n-methyl-taxol c 10-deacetyl-10-(Beta-glucopyranosyl)-yunnanxane
学科领域	Chemistry, Organic
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000180271500002
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4606
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Univ Illinois, Program Collaborat Res Pharmaceut Sci, Dept Med Chem & Pharmacognosy, Coll Pharm, Chicago, IL 60612 USA 2.Chinese Acad Sci, Lab Phytochem, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Li, SH,Zhang, HJ,Niu, XM,et al. Novel taxoids from the Chinese yew Taxus yunnanensis[J]. TETRAHEDRON,2003,59(1):37-45.
APA	Li, SH,Zhang, HJ,Niu, XM,Yao, P,Sun, HD,&Fong, HHS.(2003).Novel taxoids from the Chinese yew Taxus yunnanensis.TETRAHEDRON,59(1),37-45.
MLA	Li, SH,et al."Novel taxoids from the Chinese yew Taxus yunnanensis".TETRAHEDRON 59.1(2003):37-45.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
201202240054.pdf（210KB）			开放获取	--	浏览下载