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题名: Kansuinone, a novel euphane-type triterpene from Euphorbia kansui
作者: Guo, Jie1, 2; He, Hong-Ping2; Fang, Xin2; Di, Ying-Tong2; Li, Shun-Lin2; Zhang, Zhen2; Leng, Ying3; Hua, Hui-Ming1; null(郝小江)2
刊名: TETRAHEDRON LETTERS
关键词: Euphorbia kansui ; Euphane-type triterpene ; Structure elucidation ; 11 beta-HSD1 inhibitory activity
英文摘要: Kansuinone (1), a rearranged euphane triterpenoid containing a spiro [5,61 ring system, was isolated from the roots of Euphorbia kansui. Its structure and stereochemistry were elucidated on the basis of spectro-scopic, CD, and computational methods. Kansuinone (1) exhibited inhibitory activity against human and mouse 11 beta-HSD1 (11 beta-hydroxysteroid dehydrogenase type 1), with IC(50) values of 1.12 and 1.08 mu M, respectively. (C) 2010 Elsevier Ltd. All rights reserved.
出版日期: 2010-12-01
卷号: 51, 期号:48, 页码:6286-6289
DOI标识: 10.1016/j.tetlet.2010.09.099
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry, Organic
ISSN号: 0040-4039
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4306
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Shenyang 110016, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

Recommended Citation:
Guo, J; He, HP; Fang, X; Di, YT; Li, SL; Zhang, Z; Leng, Y; Hua, HM; Hao, XJ.Kansuinone, a novel euphane-type triterpene from Euphorbia kansui,TETRAHEDRON LETTERS,2010,51(48):6286-6289
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