Kansuinone, a novel euphane-type triterpene from Euphorbia kansui
Guo, Jie1,2; He, Hong-Ping2; Fang, Xin2; Di, Ying-Tong2; Li, Shun-Lin2; Zhang, Zhen2; Leng, Ying3; Hua, Hui-Ming1; Hao, Xiao-Jiang2
2010-12-01
发表期刊TETRAHEDRON LETTERS
ISSN0040-4039
卷号51期号:48页码:6286-6289
摘要Kansuinone (1), a rearranged euphane triterpenoid containing a spiro [5,61 ring system, was isolated from the roots of Euphorbia kansui. Its structure and stereochemistry were elucidated on the basis of spectro-scopic, CD, and computational methods. Kansuinone (1) exhibited inhibitory activity against human and mouse 11 beta-HSD1 (11 beta-hydroxysteroid dehydrogenase type 1), with IC(50) values of 1.12 and 1.08 mu M, respectively. (C) 2010 Elsevier Ltd. All rights reserved.
关键词Euphorbia Kansui Euphane-type Triterpene Structure Elucidation 11 Beta-hsd1 Inhibitory Activity
资助信息Ministry of Science and Technology of China [2009CB940900, 2009CB522300]; National Natural Science Funding of China [21072199]; Natural Science Funding of Yunnan Province [2009CD112]; Foundation of Chinese Academy of Sciences ; Yong Academic and Technical Leader Raising Foundation of Yunnan Province ; Foundation of State Key Laboratory of Phytochemistry and Plant Resource in West China [P2010-ZZ01]
学科领域Chemistry, Organic
DOI10.1016/j.tetlet.2010.09.099
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000284303200021
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4306
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Shenyang 110016, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Guo, Jie,He, Hong-Ping,Fang, Xin,et al. Kansuinone, a novel euphane-type triterpene from Euphorbia kansui[J]. TETRAHEDRON LETTERS,2010,51(48):6286-6289.
APA Guo, Jie.,He, Hong-Ping.,Fang, Xin.,Di, Ying-Tong.,Li, Shun-Lin.,...&Hao, Xiao-Jiang.(2010).Kansuinone, a novel euphane-type triterpene from Euphorbia kansui.TETRAHEDRON LETTERS,51(48),6286-6289.
MLA Guo, Jie,et al."Kansuinone, a novel euphane-type triterpene from Euphorbia kansui".TETRAHEDRON LETTERS 51.48(2010):6286-6289.
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