A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity

doi:10.1021/ol1011289

	A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity
	Wang, Fei 2,3; Gao, Yuan 3; Zhang, Ling 2; Bai, Bing 2; Hu, Ya Nan 1; Dong, Ze Jun 2; Zhai, Qi Wei 1; Zhu, Hua Jie 2; Liu, Ji Kai 2
	2010-07-16
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	12 期号:14 页码:3196-3199
摘要	(+)-Linderaspirone A and (-)-linderaspirone A, a pair of natural windmill-shaped enantiomers, were isolated from the traditional Chinese medicine plant tinders aggregate by HPLC using a chiral column, achieving over 98% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra, crystal X-ray diffraction, and calculation of the optical rotations (OR). They have an unprecedented carbon skeleton and showed significant activity against glucosamine-induced insulin resistance.
关键词	Sesquiterpene Lactones Optical-rotation Water Extract Strychnifolia Root Butanolides
学科领域	Chemistry, Organic
DOI	10.1021/ol1011289
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000279569600022
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4286
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.BioBioPha Co Ltd, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Wang, Fei,Gao, Yuan,Zhang, Ling,et al. A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity[J]. ORGANIC LETTERS,2010,12(14):3196-3199.
APA	Wang, Fei.,Gao, Yuan.,Zhang, Ling.,Bai, Bing.,Hu, Ya Nan.,...&Liu, Ji Kai.(2010).A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity.ORGANIC LETTERS,12(14),3196-3199.
MLA	Wang, Fei,et al."A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity".ORGANIC LETTERS 12.14(2010):3196-3199.

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