A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity
Wang, Fei2,3; Gao, Yuan3; Zhang, Ling2; Bai, Bing2; Hu, Ya Nan1; Dong, Ze Jun2; Zhai, Qi Wei1; Zhu, Hua Jie2; Liu, Ji Kai2
2010-07-16
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume12Issue:14Pages:3196-3199
Abstract(+)-Linderaspirone A and (-)-linderaspirone A, a pair of natural windmill-shaped enantiomers, were isolated from the traditional Chinese medicine plant tinders aggregate by HPLC using a chiral column, achieving over 98% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra, crystal X-ray diffraction, and calculation of the optical rotations (OR). They have an unprecedented carbon skeleton and showed significant activity against glucosamine-induced insulin resistance.
KeywordSesquiterpene Lactones Optical-rotation Water Extract Strychnifolia Root Butanolides
Subject AreaChemistry, Organic
DOI10.1021/ol1011289
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000279569600022
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4286
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.BioBioPha Co Ltd, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China
Recommended Citation
GB/T 7714
Wang, Fei,Gao, Yuan,Zhang, Ling,et al. A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity[J]. ORGANIC LETTERS,2010,12(14):3196-3199.
APA Wang, Fei.,Gao, Yuan.,Zhang, Ling.,Bai, Bing.,Hu, Ya Nan.,...&Liu, Ji Kai.(2010).A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity.ORGANIC LETTERS,12(14),3196-3199.
MLA Wang, Fei,et al."A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity".ORGANIC LETTERS 12.14(2010):3196-3199.
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