A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity
Wang, Fei2,3; Gao, Yuan3; Zhang, Ling2; Bai, Bing2; Hu, Ya Nan1; Dong, Ze Jun2; Zhai, Qi Wei1; Zhu, Hua Jie2; Liu, Ji Kai2
2010-07-16
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号12期号:14页码:3196-3199
摘要(+)-Linderaspirone A and (-)-linderaspirone A, a pair of natural windmill-shaped enantiomers, were isolated from the traditional Chinese medicine plant tinders aggregate by HPLC using a chiral column, achieving over 98% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra, crystal X-ray diffraction, and calculation of the optical rotations (OR). They have an unprecedented carbon skeleton and showed significant activity against glucosamine-induced insulin resistance.
关键词Sesquiterpene Lactones Optical-rotation Water Extract Strychnifolia Root Butanolides
资助信息National Basic Research Program of China (973 Program) [2009CB522300]; National Natural Science Foundation of China [30830113]; MOST [2009ZX09501-029, 2009ZX09501-013]
学科领域Chemistry, Organic
DOI10.1021/ol1011289
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000279569600022
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4286
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.BioBioPha Co Ltd, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China
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Wang, Fei,Gao, Yuan,Zhang, Ling,et al. A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity[J]. ORGANIC LETTERS,2010,12(14):3196-3199.
APA Wang, Fei.,Gao, Yuan.,Zhang, Ling.,Bai, Bing.,Hu, Ya Nan.,...&Liu, Ji Kai.(2010).A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity.ORGANIC LETTERS,12(14),3196-3199.
MLA Wang, Fei,et al."A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity".ORGANIC LETTERS 12.14(2010):3196-3199.
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