A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity | |
Wang, Fei2,3; Gao, Yuan3; Zhang, Ling2; Bai, Bing2; Hu, Ya Nan1; Dong, Ze Jun2; Zhai, Qi Wei1; Zhu, Hua Jie2; Liu, Ji Kai2 | |
2010-07-16 | |
发表期刊 | ORGANIC LETTERS
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ISSN | 1523-7060 |
卷号 | 12期号:14页码:3196-3199 |
摘要 | (+)-Linderaspirone A and (-)-linderaspirone A, a pair of natural windmill-shaped enantiomers, were isolated from the traditional Chinese medicine plant tinders aggregate by HPLC using a chiral column, achieving over 98% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra, crystal X-ray diffraction, and calculation of the optical rotations (OR). They have an unprecedented carbon skeleton and showed significant activity against glucosamine-induced insulin resistance. |
关键词 | Sesquiterpene Lactones Optical-rotation Water Extract Strychnifolia Root Butanolides |
学科领域 | Chemistry, Organic |
DOI | 10.1021/ol1011289 |
收录类别 | SCI ; IC |
语种 | 英语 |
WOS记录号 | WOS:000279569600022 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.kib.ac.cn/handle/151853/4286 |
专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
作者单位 | 1.BioBioPha Co Ltd, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Fei,Gao, Yuan,Zhang, Ling,et al. A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity[J]. ORGANIC LETTERS,2010,12(14):3196-3199. |
APA | Wang, Fei.,Gao, Yuan.,Zhang, Ling.,Bai, Bing.,Hu, Ya Nan.,...&Liu, Ji Kai.(2010).A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity.ORGANIC LETTERS,12(14),3196-3199. |
MLA | Wang, Fei,et al."A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity".ORGANIC LETTERS 12.14(2010):3196-3199. |
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