Bi-linderone, a Highly Modified Methyl-linderone Dimer from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity in Vitro
Wang, Fei1,2; Gao, Yuan2; Zhang, Ling1; Liu, Ji-Kai1
2010-05-21
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号12期号:10页码:2354-2357
摘要Bi-linderone (1) was isolated as racemate from the traditional Chinese medicinal plant Lindera aggregata. The structure elucidation of bi-linderone was reported on the basis of extensive analysis of NMR spectra and crystal X-ray diffraction. Bi-linderone has an unprecedented spirocyclopentenedione-containing carbon skeleton and showed significant activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 mu g/mL.
关键词Sesquiterpene Lactones Water Extract Strychnifolia Root Butanolides
资助信息National Basic Research Program of China [2009CB522300]; National Natural Science Foundation of China [30830113]; MOST [2009ZX09501-029, 2009ZX09501-013]
学科领域Chemistry, Organic
DOI10.1021/ol1007247
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000277531000047
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4284
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.BioBioPha Co Ltd, Kunming 656204, Peoples R China
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Wang, Fei,Gao, Yuan,Zhang, Ling,et al. Bi-linderone, a Highly Modified Methyl-linderone Dimer from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity in Vitro[J]. ORGANIC LETTERS,2010,12(10):2354-2357.
APA Wang, Fei,Gao, Yuan,Zhang, Ling,&Liu, Ji-Kai.(2010).Bi-linderone, a Highly Modified Methyl-linderone Dimer from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity in Vitro.ORGANIC LETTERS,12(10),2354-2357.
MLA Wang, Fei,et al."Bi-linderone, a Highly Modified Methyl-linderone Dimer from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity in Vitro".ORGANIC LETTERS 12.10(2010):2354-2357.
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