Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma
Yang, Jian-Hong1,3; Pu, Jian-Xin1; Wen, Jin2; Li, Xiao-Nian1; He, Fei1; Xue, Yong-Bo1; Wang, Yuan-Yuan1; Li, Yan1; Xiao, Wei-Lie1; Sun, Han-Dong1
2010
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号73期号:1页码:12-16
摘要Six new triterpene dilactones with a rare rearranged pentacyclic skeleton, longipedlactones K-P (1-6), and seven known analogues (7-13) were isolated from the stems of Kadsura ananosma. Compound I was found to possess a unique peroxide bridge between C-1 and C-9 in rings A and B. The structures of these new compounds were established on the basis of spectroscopic data analysis, especially of their 2D NMR spectra. In the evaluation of the in vitro cytotoxicity of these compounds against a small panel of human cancer cell lines, compounds 3, 7, 9, and 13 were found to be the most potent against HL-60 acute leukemia cell.
关键词Dibenzocyclooctadiene Lignans Unique Skeleton Coccinea Philippinensis Interior Longipedunculata Heteroclita Acids
资助信息NSFC [30830115, 2008GA031]; Major State Basic Research Development Program of China [2009CB522300, 2009CB940900]; Western Doctoral Foundation of Chinese Academy of Sciences ; Drug Development front Five Medicinal Plants in West China [KZCX2-XB2-15]
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np900506g
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000273654000004
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4232
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Yunnan Acad Forest Sci, Inst Trop Forestry, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Yang, Jian-Hong,Pu, Jian-Xin,Wen, Jin,et al. Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(1):12-16.
APA Yang, Jian-Hong.,Pu, Jian-Xin.,Wen, Jin.,Li, Xiao-Nian.,He, Fei.,...&Sun, Han-Dong.(2010).Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma.JOURNAL OF NATURAL PRODUCTS,73(1),12-16.
MLA Yang, Jian-Hong,et al."Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma".JOURNAL OF NATURAL PRODUCTS 73.1(2010):12-16.
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