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题名: Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma
作者: Yang, Jian-Hong1, 3; Pu, Jian-Xin1; Wen, Jin2; Li, Xiao-Nian1; He, Fei1; Xue, Yong-Bo1; Wang, Yuan-Yuan1; null(李艳)1; Xiao, Wei-Lie1; null(孙汉董)1
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: DIBENZOCYCLOOCTADIENE LIGNANS ; UNIQUE SKELETON ; COCCINEA ; PHILIPPINENSIS ; INTERIOR ; LONGIPEDUNCULATA ; HETEROCLITA ; ACIDS
英文摘要: Six new triterpene dilactones with a rare rearranged pentacyclic skeleton, longipedlactones K-P (1-6), and seven known analogues (7-13) were isolated from the stems of Kadsura ananosma. Compound I was found to possess a unique peroxide bridge between C-1 and C-9 in rings A and B. The structures of these new compounds were established on the basis of spectroscopic data analysis, especially of their 2D NMR spectra. In the evaluation of the in vitro cytotoxicity of these compounds against a small panel of human cancer cell lines, compounds 3, 7, 9, and 13 were found to be the most potent against HL-60 acute leukemia cell.
出版日期: 2010
卷号: 73, 期号:1, 页码:12-16
DOI标识: 10.1021/np900506g
语种: 英语
收录类别: SCI ; IC
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4232
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Yunnan Acad Forest Sci, Inst Trop Forestry, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Yang, JH; Pu, JX; Wen, J; Li, XN; He, F; Xue, YB; Wang, YY; Li, Y; Xiao, WL; Sun, HD.Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma,JOURNAL OF NATURAL PRODUCTS,2010,73(1):12-16
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