Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma

doi:10.1021/np900506g

	Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma
	Yang, Jian-Hong 1,3; Pu, Jian-Xin1 ; Wen, Jin 2; Li, Xiao-Nian 1; He, Fei 1; Xue, Yong-Bo 1; Wang, Yuan-Yuan 1; Li, Yan1 ; Xiao, Wei-Lie 1; Sun, Han-Dong1
	2010
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	73 期号:1 页码:12-16
摘要	Six new triterpene dilactones with a rare rearranged pentacyclic skeleton, longipedlactones K-P (1-6), and seven known analogues (7-13) were isolated from the stems of Kadsura ananosma. Compound I was found to possess a unique peroxide bridge between C-1 and C-9 in rings A and B. The structures of these new compounds were established on the basis of spectroscopic data analysis, especially of their 2D NMR spectra. In the evaluation of the in vitro cytotoxicity of these compounds against a small panel of human cancer cell lines, compounds 3, 7, 9, and 13 were found to be the most potent against HL-60 acute leukemia cell.
关键词	Dibenzocyclooctadiene Lignans Unique Skeleton Coccinea Philippinensis Interior Longipedunculata Heteroclita Acids
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1021/np900506g
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000273654000004
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4232
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Yunnan Acad Forest Sci, Inst Trop Forestry, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Yang, Jian-Hong,Pu, Jian-Xin,Wen, Jin,et al. Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(1):12-16.
APA	Yang, Jian-Hong.,Pu, Jian-Xin.,Wen, Jin.,Li, Xiao-Nian.,He, Fei.,...&Sun, Han-Dong.(2010).Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma.JOURNAL OF NATURAL PRODUCTS,73(1),12-16.
MLA	Yang, Jian-Hong,et al."Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma".JOURNAL OF NATURAL PRODUCTS 73.1(2010):12-16.

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